Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease

BackgroundThe genetic basis of stroke susceptibility remains to be elucidated. STR1 quantitative trait locus (STR1/QTL) was identified on rat chromosome 1 of stroke‐prone spontaneously hypertensive rat (SHRSP) upon Japanese‐style stroke‐permissive diet (JD), and it contributes to 20% of the stroke p...

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Main Authors: Speranza Rubattu, Sara Di Castro, Herbert Schulz, Aron M. Geurts, Maria Cotugno, Franca Bianchi, Henrike Maatz, Oliver Hummel, Samreen Falak, Rosita Stanzione, Simona Marchitti, Stefania Scarpino, Betti Giusti, Ada Kura, Gian Franco Gensini, Flora Peyvandi, Pier Mannuccio Mannucci, Maurizia Rasura, Sebastiano Sciarretta, Melinda R. Dwinell, Norbert Hubner, Massimo Volpe
Format: Article
Language:English
Published: Wiley 2016-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
complex I
early‐onset ischemic stroke
knockout rat model
mitochondria
Ndufc2
stroke‐prone spontaneously hypertensive rat
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002701

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