Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants
Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders and mortality. Further, maternal PTSD is associa...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15592294.2023.2231722 |
| _version_ | 1797678842258653184 |
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| author | Seyma Katrinli Alicia K Smith Stacy S. Drury Jonathan Covault Julian D. Ford Vijender Singh Bo Reese Amy Johnson Victoria Scranton Pamela Fall Margaret Briggs-Gowan Damion J Grasso |
| author_facet | Seyma Katrinli Alicia K Smith Stacy S. Drury Jonathan Covault Julian D. Ford Vijender Singh Bo Reese Amy Johnson Victoria Scranton Pamela Fall Margaret Briggs-Gowan Damion J Grasso |
| author_sort | Seyma Katrinli |
| collection | DOAJ |
| description | Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders and mortality. Further, maternal PTSD is associated with gestational epigenetic age acceleration in newborns, implicating the prenatal period as a developmental time period for the transmission of effects across generations. Here, we evaluated the associations between PTSD symptoms, maternal epigenetic age acceleration, and infant gestational epigenetic age acceleration in 89 maternal-neonatal dyads. Trauma-related experiences and PTSD symptoms in mothers were assessed during the third trimester of pregnancy. The MethylationEPIC array was used to generate DNA methylation data from maternal and neonatal saliva samples collected within 24 h of infant birth. Maternal epigenetic age acceleration was calculated using Horvath’s multi-tissue clock, PhenoAge and GrimAge. Gestational epigenetic age was estimated using the Haftorn clock. Maternal cumulative past-year stress (GrimAge: p = 3.23e-04, PhenoAge: p = 9.92e-03), PTSD symptoms (GrimAge: p = 0.019), and difficulties in emotion regulation (GrimAge: p = 0.028) were associated with accelerated epigenetic age in mothers. Maternal PTSD symptoms were associated with lower gestational epigenetic age acceleration in neonates (p = 0.032). Overall, our results suggest that maternal cumulative past-year stress exposure and trauma-related symptoms may increase the risk for age-related problems in mothers and developmental problems in their newborns. |
| first_indexed | 2024-03-11T23:05:01Z |
| format | Article |
| id | doaj.art-bb1399382ce142ef8bd7711260c0bb0d |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-11T23:05:01Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-bb1399382ce142ef8bd7711260c0bb0d2023-09-21T13:23:13ZengTaylor & Francis GroupEpigenetics1559-22941559-23082023-12-0118110.1080/15592294.2023.22317222231722Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infantsSeyma Katrinli0Alicia K Smith1Stacy S. Drury2Jonathan Covault3Julian D. Ford4Vijender Singh5Bo Reese6Amy Johnson7Victoria Scranton8Pamela Fall9Margaret Briggs-Gowan10Damion J Grasso11Emory University School of MedicineEmory University School of MedicineDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Harvard Medical School, Boston, MA, USAUniversity of Connecticut School of MedicineUniversity of Connecticut School of MedicineUniversity of Connecticut, School of MedicineUniversity of ConnecticutHartford HospitalUniversity of Connecticut School of MedicineUniversity of Connecticut School of MedicineUniversity of Connecticut School of MedicineUniversity of Connecticut School of MedicinePregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity and emotional dysregulation, as well as increased risk of chronic disorders and mortality. Further, maternal PTSD is associated with gestational epigenetic age acceleration in newborns, implicating the prenatal period as a developmental time period for the transmission of effects across generations. Here, we evaluated the associations between PTSD symptoms, maternal epigenetic age acceleration, and infant gestational epigenetic age acceleration in 89 maternal-neonatal dyads. Trauma-related experiences and PTSD symptoms in mothers were assessed during the third trimester of pregnancy. The MethylationEPIC array was used to generate DNA methylation data from maternal and neonatal saliva samples collected within 24 h of infant birth. Maternal epigenetic age acceleration was calculated using Horvath’s multi-tissue clock, PhenoAge and GrimAge. Gestational epigenetic age was estimated using the Haftorn clock. Maternal cumulative past-year stress (GrimAge: p = 3.23e-04, PhenoAge: p = 9.92e-03), PTSD symptoms (GrimAge: p = 0.019), and difficulties in emotion regulation (GrimAge: p = 0.028) were associated with accelerated epigenetic age in mothers. Maternal PTSD symptoms were associated with lower gestational epigenetic age acceleration in neonates (p = 0.032). Overall, our results suggest that maternal cumulative past-year stress exposure and trauma-related symptoms may increase the risk for age-related problems in mothers and developmental problems in their newborns.http://dx.doi.org/10.1080/15592294.2023.2231722ptsdgrimagegestational epigenetic agedna methylation |
| spellingShingle | Seyma Katrinli Alicia K Smith Stacy S. Drury Jonathan Covault Julian D. Ford Vijender Singh Bo Reese Amy Johnson Victoria Scranton Pamela Fall Margaret Briggs-Gowan Damion J Grasso Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants Epigenetics ptsd grimage gestational epigenetic age dna methylation |
| title | Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants |
| title_full | Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants |
| title_fullStr | Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants |
| title_full_unstemmed | Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants |
| title_short | Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants |
| title_sort | cumulative stress ptsd and emotion dysregulation during pregnancy and epigenetic age acceleration in hispanic mothers and their newborn infants |
| topic | ptsd grimage gestational epigenetic age dna methylation |
| url | http://dx.doi.org/10.1080/15592294.2023.2231722 |
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