Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities
Micheliolide (MCL) is a chief constituent of plants such as Magnolia grandiflora L., Michelia compressa (Maxim.) Sarg. and Michelia champaca L. It is known to exhibit significant anticancer activity by various scientific investigations. This review aims to emphasize the anticancer and antiinflammato...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024033309 |
| _version_ | 1797224289717452800 |
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| author | Jalal Uddin Mehwish Fatima Ammara Riaz Ghulam Mustafa Kamal Abdullatif Bin Muhsinah Abdul Razzaq Ahmed Ramsha Iftikhar |
| author_facet | Jalal Uddin Mehwish Fatima Ammara Riaz Ghulam Mustafa Kamal Abdullatif Bin Muhsinah Abdul Razzaq Ahmed Ramsha Iftikhar |
| author_sort | Jalal Uddin |
| collection | DOAJ |
| description | Micheliolide (MCL) is a chief constituent of plants such as Magnolia grandiflora L., Michelia compressa (Maxim.) Sarg. and Michelia champaca L. It is known to exhibit significant anticancer activity by various scientific investigations. This review aims to emphasize the anticancer and antiinflammatory activities of MCL. In this review, we summarized the published data in peer-reviewed manuscripts published in English. Our search was based on the following scientific search engines and databases: Scopus, Google Scholar, ScienceDirect, Springer, PubMed, and SciFinder, MCL possesses a broad spectrum of medicinal properties like other sesquiterpene lactones. The anticancer activity of this compound may be attributed to the modulation of several signaling cascades (PI3K/Akt and NF-κB pathways). It also induces apoptosis by arresting the cell cycle at the G1/G0 phase, S phase, and G2/M phase in many cancer cell lines. Very little data is available on its modulatory action on other signaling cascades like MAPK, STAT3, Wnt, TGFβ, Notch, EGFR, etc. This compound can be potentiated as a novel anticancer drug after thorough investigations in vitro, in vivo, and in silico-based studies. |
| first_indexed | 2024-04-24T13:50:45Z |
| format | Article |
| id | doaj.art-bb184a33f6304033981fcfd468ec8db6 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:50:45Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-bb184a33f6304033981fcfd468ec8db62024-04-04T05:04:35ZengElsevierHeliyon2405-84402024-03-01106e27299Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activitiesJalal Uddin0Mehwish Fatima1Ammara Riaz2Ghulam Mustafa Kamal3Abdullatif Bin Muhsinah4Abdul Razzaq Ahmed5Ramsha Iftikhar6Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Asir, 61421, Saudi Arabia; Corresponding author.Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, PakistanDepartment of Life Sciences, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, 64200, PakistanInstitute of Chemistry, Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan, 64200, Pakistan; Corresponding author. Institute of Chemistry, Faculty of Natural and Applied Sciences, Khwaja Fareed University of Engineering and Information Technology, University, Rahim Yar Khan, 64200, Pakistan.Department of Pharmacognosy, College of Pharmacy, King Khalid University, Asir, 61421, Saudi ArabiaDepartment of Prosthodontics, College of Dentistry, King Khalid University, Abha, 61421, Saudi ArabiaSchool of Chemistry, University of New South Wales, 2033, Sydney, AustraliaMicheliolide (MCL) is a chief constituent of plants such as Magnolia grandiflora L., Michelia compressa (Maxim.) Sarg. and Michelia champaca L. It is known to exhibit significant anticancer activity by various scientific investigations. This review aims to emphasize the anticancer and antiinflammatory activities of MCL. In this review, we summarized the published data in peer-reviewed manuscripts published in English. Our search was based on the following scientific search engines and databases: Scopus, Google Scholar, ScienceDirect, Springer, PubMed, and SciFinder, MCL possesses a broad spectrum of medicinal properties like other sesquiterpene lactones. The anticancer activity of this compound may be attributed to the modulation of several signaling cascades (PI3K/Akt and NF-κB pathways). It also induces apoptosis by arresting the cell cycle at the G1/G0 phase, S phase, and G2/M phase in many cancer cell lines. Very little data is available on its modulatory action on other signaling cascades like MAPK, STAT3, Wnt, TGFβ, Notch, EGFR, etc. This compound can be potentiated as a novel anticancer drug after thorough investigations in vitro, in vivo, and in silico-based studies.http://www.sciencedirect.com/science/article/pii/S2405844024033309MicheliolideA sesquiterpene lactoneMagnolia grandiflora LAnticancerAnti-inflammatory |
| spellingShingle | Jalal Uddin Mehwish Fatima Ammara Riaz Ghulam Mustafa Kamal Abdullatif Bin Muhsinah Abdul Razzaq Ahmed Ramsha Iftikhar Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities Heliyon Micheliolide A sesquiterpene lactone Magnolia grandiflora L Anticancer Anti-inflammatory |
| title | Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities |
| title_full | Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities |
| title_fullStr | Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities |
| title_full_unstemmed | Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities |
| title_short | Pharmacological potential of micheliolide: A focus on anti-inflammatory and anticancer activities |
| title_sort | pharmacological potential of micheliolide a focus on anti inflammatory and anticancer activities |
| topic | Micheliolide A sesquiterpene lactone Magnolia grandiflora L Anticancer Anti-inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024033309 |
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