Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S]
Heritability of LPA allele, apo(a) isoform sizes, and isoform-associated lipoprotein(a) [Lp(a)] levels was studied in 82 Caucasian and African-American families with two parents and two children (age: 6–74 years). We determined: 1) Lp(a) levels; 2) LPA allele sizes; 3) apo(a) isoform sizes; and 4) i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S002222752032321X |
| _version_ | 1818406310594478080 |
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| author | Byambaa Enkhmaa Erdembileg Anuurad Wei Zhang Kyoungmi Kim Lars Berglund |
| author_facet | Byambaa Enkhmaa Erdembileg Anuurad Wei Zhang Kyoungmi Kim Lars Berglund |
| author_sort | Byambaa Enkhmaa |
| collection | DOAJ |
| description | Heritability of LPA allele, apo(a) isoform sizes, and isoform-associated lipoprotein(a) [Lp(a)] levels was studied in 82 Caucasian and African-American families with two parents and two children (age: 6–74 years). We determined: 1) Lp(a) levels; 2) LPA allele sizes; 3) apo(a) isoform sizes; and 4) isoform-specific apo(a) levels (ISLs), the amount of Lp(a) carried by an individual apo(a) isoform. Trait heritability was estimated by mid-parent-offspring analysis. The ethnicity-adjusted heritability estimate for Lp(a) level was 0.95. Heritability for ISLs corresponding to the smaller LPA allele in a given allele-pair was higher than that corresponding to the larger LPA allele (0.91 vs. 0.59, P = 0.017). Although not statistically different, heritability for both apo(a) isoforms (0.90 vs. 0.70) and LPA alleles (0.98 vs. 0.82) was higher for the smaller versus larger sizes. Heritability was generally lower in African-Americans versus Caucasians with a 4-fold difference for the larger LPA allele (0.25 vs. 0.94, P = 0.001). In Caucasians, an overall higher heritability pattern was noted for the older (≥47 years) versus younger (<47 years) families. In conclusion, Lp(a) level and traits associated with the smaller LPA alleles were strongly determined by genetics, although with a varying ethnic influence. Ethnic differences in heritability of the larger LPA allele warrant further investigations. |
| first_indexed | 2024-12-14T09:09:55Z |
| format | Article |
| id | doaj.art-bb194aca06cc45da896f93f62495f573 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-14T09:09:55Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-bb194aca06cc45da896f93f62495f5732022-12-21T23:08:36ZengElsevierJournal of Lipid Research0022-22752019-09-0160916031609Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S]Byambaa Enkhmaa0Erdembileg Anuurad1Wei Zhang2Kyoungmi Kim3Lars Berglund4To whom correspondence should be addressed.; Departments of Internal MedicineUniversity of California Davis, Davis, CADepartments of Internal MedicineUniversity of California Davis, Davis, CADepartments of Internal MedicineUniversity of California Davis, Davis, CAPublic Health Sciences University of California Davis, Davis, CADepartments of Internal MedicineUniversity of California Davis, Davis, CAHeritability of LPA allele, apo(a) isoform sizes, and isoform-associated lipoprotein(a) [Lp(a)] levels was studied in 82 Caucasian and African-American families with two parents and two children (age: 6–74 years). We determined: 1) Lp(a) levels; 2) LPA allele sizes; 3) apo(a) isoform sizes; and 4) isoform-specific apo(a) levels (ISLs), the amount of Lp(a) carried by an individual apo(a) isoform. Trait heritability was estimated by mid-parent-offspring analysis. The ethnicity-adjusted heritability estimate for Lp(a) level was 0.95. Heritability for ISLs corresponding to the smaller LPA allele in a given allele-pair was higher than that corresponding to the larger LPA allele (0.91 vs. 0.59, P = 0.017). Although not statistically different, heritability for both apo(a) isoforms (0.90 vs. 0.70) and LPA alleles (0.98 vs. 0.82) was higher for the smaller versus larger sizes. Heritability was generally lower in African-Americans versus Caucasians with a 4-fold difference for the larger LPA allele (0.25 vs. 0.94, P = 0.001). In Caucasians, an overall higher heritability pattern was noted for the older (≥47 years) versus younger (<47 years) families. In conclusion, Lp(a) level and traits associated with the smaller LPA alleles were strongly determined by genetics, although with a varying ethnic influence. Ethnic differences in heritability of the larger LPA allele warrant further investigations.http://www.sciencedirect.com/science/article/pii/S002222752032321Xlipoprotein (a)apolipoprotein (a) isoformLPA alleleheritability estimatesfamily resemblancefamily study |
| spellingShingle | Byambaa Enkhmaa Erdembileg Anuurad Wei Zhang Kyoungmi Kim Lars Berglund Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S] Journal of Lipid Research lipoprotein (a) apolipoprotein (a) isoform LPA allele heritability estimates family resemblance family study |
| title | Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S] |
| title_full | Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S] |
| title_fullStr | Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S] |
| title_full_unstemmed | Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S] |
| title_short | Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families[S] |
| title_sort | heritability of apolipoprotein a traits in two generational african american and caucasian families s |
| topic | lipoprotein (a) apolipoprotein (a) isoform LPA allele heritability estimates family resemblance family study |
| url | http://www.sciencedirect.com/science/article/pii/S002222752032321X |
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