The Impact of Age Difference on the Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis

The Impact of Age Difference on the Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis

ObjectiveThis meta-analysis compared the efficacy and safety of five kinds of COVID-19 vaccines in different age groups (young adults and older adults), aiming to analyze the difference of adverse events (AEs) rate and virus geometric mean titer (GMT) values between young and older people, in order...

Full description

Bibliographic Details
Main Authors:	Jiting Wang, Yue Tong, Duo Li, Jun Li, Yaling Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-12-01
Series:	Frontiers in Immunology
Subjects:	efficacy and safety COVID-19 vaccines age randomized-controlled trials (RCT) double-blind meta-analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.758294/full

Similar Items

Efficacy and Safety of Camrelizumab Monotherapy and Combination Therapy for Cancers: A Systematic Review and Meta-Analysis
by: Jiting Wang, et al.
Published: (2021-06-01)

Multiple Comparisons of the Efficacy and Safety for Seven Treatments in Tibia Shaft Fracture Patients
by: Haibo Li, et al.
Published: (2019-04-01)

Impact of vaccination with different types of rotavirus vaccines on the incidence of intussusception: a randomized controlled meta-analysis
by: Guoyong Wang, et al.
Published: (2023-07-01)

Efficacy, immunogenicity and safety of COVID-19 vaccines in older adults: a systematic review and meta-analysis
by: Zejun Li, et al.
Published: (2022-09-01)

Efficacy and Safety of Eldecalcitol for Osteoporosis: A Meta-Analysis of Randomized Controlled Trials
by: Hongyan Liu, et al.
Published: (2022-04-01)

Comparative efficacy and safety of JAK inhibitors in the treatment of moderate-to-severe alopecia areata: a systematic review and network meta-analysis
by: Ting Yan, et al.
Published: (2024-04-01)

Treatment options for recurrent platinum-resistant ovarian cancer: A systematic review and Bayesian network meta-analysis based on RCTs
by: Juan Li, et al.
Published: (2023-04-01)

Efficacy, immunogenicity and safety of HPV vaccination in Chinese population: A meta-analysis
by: Jianming Guo, et al.
Published: (2023-02-01)

A Randomized, Double-Blind, Parallel Study to Evaluate the Dose-Response of Three Different Vitamin D Treatment Schemes on the 25-Hydroxyvitamin D Serum Concentration in Patients with Vitamin D Deficiency
by: Marie-Louise Schleck, et al.
Published: (2015-07-01)

Efficacy and Safety of COVID-19 Vaccines in Phase III Trials: A Meta-Analysis
by: Haoyue Cheng, et al.
Published: (2021-06-01)

Efficacy and safety of total glucosides of paeony as an add-on treatment in adolescents and adults with chronic urticaria: A systematic review and meta-analysis
by: Ming Li, et al.
Published: (2022-09-01)

Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial
by: Hidemasa Torii, et al.
Published: (2022-10-01)

Efficacy, Immunogenicity and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis
by: Nadim Sharif, et al.
Published: (2021-10-01)

The safety and efficacy of acceptance and commitment therapy against psychotic symptomatology: a systematic review and meta-analysis
by: Ellie Brown, et al.
Published: (2020-08-01)

Efficacy and Safety of <i>Bifidobacterium longum</i> Supplementation in Infants: A Meta-Analysis of Randomized Controlled Trials
by: Huangda Guo, et al.
Published: (2023-12-01)

Analgesic efficacy of diazepam and placebo in patients with temporomandibular disorders: A double blind randomized clinical trial
by: G V Pramod, et al.
Published: (2011-01-01)

Safety and Efficacy of Tranexamic Acid in Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis of Randomized Controlled Trials
by: Junwei Ren, et al.
Published: (2022-01-01)

Efficacy of apremilast for psoriasis: a meta-analysis of randomized controlled studies
by: Yashu Liu, et al.
Published: (2022-09-01)

Efficacy and safety of daily home-based transcranial direct current stimulation as adjunct treatment for bipolar depressive episodes: Double-blind sham-controlled randomized clinical trial
by: Jangwon Lee, et al.
Published: (2022-09-01)

The Efficacy and Safety of Mirabegron for the Treatment of Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review and Meta-analysis
by: Dongxu Zhang, et al.
Published: (2021-11-01)

Efficacy and safety of prophylactic HPV vaccines. A Cochrane review of randomized trials
by: M. Arbyn, et al.
Published: (2018-12-01)

Mini-Review on the efficacy and safety of pitavastatin: “The novel seventh statin gaining momentum”
by: Azza Ramadan, et al.
Published: (2022-01-01)

Assessing the Efficacy and Mechanisms of Pycnogenol® on Cognitive Aging From In Vitro Animal and Human Studies
by: Tamara Simpson, et al.
Published: (2019-07-01)

Systematic Review and Meta-Analysis of the Efficacy and Safety of Enhanced Recovery After Surgery vs. Conventional Recovery After Surgery on Perioperative Outcomes of Radical Cystectomy
by: Dongxu Zhang, et al.
Published: (2020-09-01)

Efficacy and safety of COVID-19 inactivated vaccine: A meta-analysis
by: Xiaoming Li, et al.
Published: (2022-11-01)

The unblinding of statisticians in clinical trials: commentary on Iflaifel et al., Trials 2023
by: Richard A. Parker
Published: (2023-09-01)

The Efficacy and Safety of Brolucizumab for the Treatment of nAMD: A Systematic Review and Meta-Analysis
by: Junlan Chuan, et al.
Published: (2022-05-01)

Safety of SARS-CoV-2 vaccines: a systematic review and meta-analysis of randomized controlled trials
by: Musha Chen, et al.
Published: (2021-07-01)

The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review
by: Qilong Nie, et al.
Published: (2024-03-01)

Efficacy and safety of human papillomavirus vaccine for primary prevention of cervical cancer: A review of evidence from phase III trials and national programs
by: Partha Basu, et al.
Published: (2013-01-01)

Efficacy and Safety of Placebo During the Maintenance Therapy of Ovarian Cancer in Randomized Controlled Trials: A Systematic Review and Meta-analysis
by: Jin-feng Wang, et al.
Published: (2022-05-01)

Implications for blinding in clinical trials with THC-containing cannabinoids based on the CANNA-TICS trial
by: Kirsten R. Müller-Vahl, et al.
Published: (2022-09-01)

Efficacy and safety of glucocorticoid in the treatment of sepsis: A systematic review and meta-analysis
by: Hua Zou, et al.
Published: (2023-07-01)

Efficacy and safety of intraocular implants: a Meta-analysis
by: Ren-Liang Huang, et al.
Published: (2016-07-01)

Safety and efficacy of tuberculosis vaccine candidates in low- and middle-income countries: a systematic review of randomised controlled clinical trials
by: Lydia Wilson, et al.
Published: (2023-02-01)

Safety, Immunogenicity, and Efficacy of COVID-19 Vaccines in Adolescents, Children, and Infants: A Systematic Review and Meta-Analysis
by: Yuxuan Du, et al.
Published: (2022-04-01)

Safety and efficacy assessment of skin gel containing nanoemulsion of Phyllanthus emblica extract: A randomized, double-blind, placebo-controlled study
by: Bungorn Sripanidkulchai, et al.
Published: (2020-04-01)

Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
by: Ali Pormohammad, et al.
Published: (2021-05-01)

Meta-analytic evidence on the efficacy of hypnosis for mental and somatic health issues: a 20-year perspective
by: Jenny Rosendahl, et al.
Published: (2024-01-01)

Safety, immunogenicity, and efficacy of an mRNA COVID-19 vaccine (RQ3013) given as the fourth booster following three doses of inactivated vaccines: a double-blinded, randomised, controlled, phase 3b trialResearch in context
by: Xiaoqiang Liu, et al.
Published: (2023-10-01)