Dovitinib preferentially targets endothelial cells rather than cancer cells for the inhibition of hepatocellular carcinoma growth and metastasis

Dovitinib preferentially targets endothelial cells rather than cancer cells for the inhibition of hepatocellular carcinoma growth and metastasis

<p>Abstract</p> <p>Background</p> <p>Dovitinib is a receptor tyrosine kinase (RTK) inhibitor targeting vascular endothelial growth factor receptors, fibroblast growth factor receptors and platelet-derived growth factor receptor β. Dovitinib is currently in clinical tria...

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Bibliographic Details
Main Authors:	Chen Zhi-Yuan, Shi Ming, Peng Li-Xia, Wei Wei, Li Xin-Jian, Guo Zhi-Xing, Li Shu-Hong, Zhong Chong, Qian Chao-Nan, Guo Rong-Ping
Format:	Article
Language:	English
Published:	BMC 2012-12-01
Series:	Journal of Translational Medicine
Subjects:	Dovitinib Endothelial cells Hepatocellular carcinoma Tumor growth Tumor metastasis
Online Access:	http://www.translational-medicine.com/content/10/1/245

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