MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

During inflammation and infection, hematopoietic stem and progenitor cells are stimulated to proliferate and differentiate into mature immune cells, especially of the myeloid lineage. MicroRNA-146a (miR-146a) is a critical negative regulator of inflammation. Deletion of miR-146a produces effects tha...

Full description

Bibliographic Details
Main Authors: Jimmy L Zhao, Dinesh S Rao, Ryan M O’Connell, Yvette Garcia-Flores, David Baltimore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-05-01
Series:eLife
Subjects:
hematopoiesis
inflammation
microRNA
HSC
cancer
NF-kappaB
Online Access:https://elifesciences.org/articles/00537

Similar Items

Similar Items