Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trial
Abstract Background The concept of periodontal regeneration has been revolutionised since the introduction of growth factors and bioactive bone substitutes which ensures optimal regeneration of the diseased periodontium. The aim of the present study was to evaluate the efficacy of Amniotic membrane ...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2021-05-01
|
| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40824-021-00217-7 |
| _version_ | 1797288660071088128 |
|---|---|
| author | Nivedha Venkatesan Vamsi Lavu S. K. Balaji |
| author_facet | Nivedha Venkatesan Vamsi Lavu S. K. Balaji |
| author_sort | Nivedha Venkatesan |
| collection | DOAJ |
| description | Abstract Background The concept of periodontal regeneration has been revolutionised since the introduction of growth factors and bioactive bone substitutes which ensures optimal regeneration of the diseased periodontium. The aim of the present study was to evaluate the efficacy of Amniotic membrane + Biphasic Calcium phosphate as compared to Collagen membrane + Biphasic Calcium phosphate for the management of periodontal intrabony defects. Methods 50 systemically healthy patients with localised moderate to severe periodontitis, sites which had a Probing Pocket Depth (PPD) ≥ 6 mm and an intrabony component of ≥ 3 mm as detected on Intra oral periapical radiographs (IOPAR) and bone sounding were recruited based on specific inclusion and exclusion criteria. They were randomly allocated by computer generated tables to Collagen membrane + Biphasic Calcium phosphate and Amniotic membrane + Biphasic Calcium phosphate groups. The amount of bone fill and changes in Probing Pocket Depth, Clinical Attachment Level were measured at baseline and six months. Results The results of the present study showed a mean reduction in the PPD of 2.89 ± 0.69 mm in the Collagen membrane + Biphasic Calcium phosphate group and 2.95 ± 0.57 mm in the Amniotic membrane + Biphasic Calcium phosphate group and CAL gain of 2.60 ± 1.43 mm in Collagen membrane + Biphasic Calcium phosphate group 3.18 ± 1.13 mm in the Amniotic membrane + Biphasic Calcium phosphate group at 6 months follow-up with no statistical significance between the groups. In terms of Defect resolution, 98.62 ± 6.51 % was achieved in Collagen membrane + Biphasic Calcium phosphate group and 98.25 ± 7.21 % in Amniotic membrane + Biphasic Calcium phosphate group. Conclusions Within the limitations of the present study, it can be concluded that AM can be used as a barrier membrane, in conjunction with Biphasic calcium phosphate, and provides comparable results to Collagen membrane with Biphasic calcium phosphate when used in the management of periodontal intrabony defects. |
| first_indexed | 2024-03-07T18:52:42Z |
| format | Article |
| id | doaj.art-bb1e037261b04884bf8692bf4d80815e |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T18:52:42Z |
| publishDate | 2021-05-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-bb1e037261b04884bf8692bf4d80815e2024-03-02T01:12:50ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242021-05-012511910.1186/s40824-021-00217-7Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trialNivedha Venkatesan0Vamsi Lavu1S. K. Balaji2Department of Periodontology, Sri Ramachandra Institute of Higher Education and ResearchDepartment of Periodontology, Sri Ramachandra Institute of Higher Education and ResearchDepartment of Periodontology, Sri Ramachandra Institute of Higher Education and ResearchAbstract Background The concept of periodontal regeneration has been revolutionised since the introduction of growth factors and bioactive bone substitutes which ensures optimal regeneration of the diseased periodontium. The aim of the present study was to evaluate the efficacy of Amniotic membrane + Biphasic Calcium phosphate as compared to Collagen membrane + Biphasic Calcium phosphate for the management of periodontal intrabony defects. Methods 50 systemically healthy patients with localised moderate to severe periodontitis, sites which had a Probing Pocket Depth (PPD) ≥ 6 mm and an intrabony component of ≥ 3 mm as detected on Intra oral periapical radiographs (IOPAR) and bone sounding were recruited based on specific inclusion and exclusion criteria. They were randomly allocated by computer generated tables to Collagen membrane + Biphasic Calcium phosphate and Amniotic membrane + Biphasic Calcium phosphate groups. The amount of bone fill and changes in Probing Pocket Depth, Clinical Attachment Level were measured at baseline and six months. Results The results of the present study showed a mean reduction in the PPD of 2.89 ± 0.69 mm in the Collagen membrane + Biphasic Calcium phosphate group and 2.95 ± 0.57 mm in the Amniotic membrane + Biphasic Calcium phosphate group and CAL gain of 2.60 ± 1.43 mm in Collagen membrane + Biphasic Calcium phosphate group 3.18 ± 1.13 mm in the Amniotic membrane + Biphasic Calcium phosphate group at 6 months follow-up with no statistical significance between the groups. In terms of Defect resolution, 98.62 ± 6.51 % was achieved in Collagen membrane + Biphasic Calcium phosphate group and 98.25 ± 7.21 % in Amniotic membrane + Biphasic Calcium phosphate group. Conclusions Within the limitations of the present study, it can be concluded that AM can be used as a barrier membrane, in conjunction with Biphasic calcium phosphate, and provides comparable results to Collagen membrane with Biphasic calcium phosphate when used in the management of periodontal intrabony defects.https://doi.org/10.1186/s40824-021-00217-7Alveolar bone lossAmniotic membraneChronic periodontitisGuided tissue regenerationRandomized Controlled Trial |
| spellingShingle | Nivedha Venkatesan Vamsi Lavu S. K. Balaji Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trial Biomaterials Research Alveolar bone loss Amniotic membrane Chronic periodontitis Guided tissue regeneration Randomized Controlled Trial |
| title | Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trial |
| title_full | Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trial |
| title_fullStr | Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trial |
| title_full_unstemmed | Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trial |
| title_short | Clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects- a randomized controlled clinical trial |
| title_sort | clinical efficacy of amniotic membrane with biphasic calcium phosphate in guided tissue regeneration of intrabony defects a randomized controlled clinical trial |
| topic | Alveolar bone loss Amniotic membrane Chronic periodontitis Guided tissue regeneration Randomized Controlled Trial |
| url | https://doi.org/10.1186/s40824-021-00217-7 |
| work_keys_str_mv | AT nivedhavenkatesan clinicalefficacyofamnioticmembranewithbiphasiccalciumphosphateinguidedtissueregenerationofintrabonydefectsarandomizedcontrolledclinicaltrial AT vamsilavu clinicalefficacyofamnioticmembranewithbiphasiccalciumphosphateinguidedtissueregenerationofintrabonydefectsarandomizedcontrolledclinicaltrial AT skbalaji clinicalefficacyofamnioticmembranewithbiphasiccalciumphosphateinguidedtissueregenerationofintrabonydefectsarandomizedcontrolledclinicaltrial |