The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients
Abstract Background Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour cell adhesion in adenocarcinomas; however, its importance in GC remains...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-022-09339-0 |
| _version_ | 1818357113474252800 |
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| author | Keisuke Goto Masaki Morimoto Mitsuhiko Osaki Akimitsu Tanio Runa Izutsu Yoshiyuki Fujiwara Futoshi Okada |
| author_facet | Keisuke Goto Masaki Morimoto Mitsuhiko Osaki Akimitsu Tanio Runa Izutsu Yoshiyuki Fujiwara Futoshi Okada |
| author_sort | Keisuke Goto |
| collection | DOAJ |
| description | Abstract Background Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour cell adhesion in adenocarcinomas; however, its importance in GC remains undetermined. Methods We analyzed AMIGO2 expression by immunohistochemistry using the specific monoclonal antibody for human AMIGO2 in 128 patients who underwent GC surgery to evaluate its relationship between various metastatic and clinical outcomes in GC. Results Immunohistochemistry revealed that AMIGO2 expression was an independent prognostic factor for overall survival, disease-specific survival, and liver metastasis in GC patients. Conclusions This study showed that AMIGO2 is induced in GC tissues and can mediate hepatic metastasis. Determining AMIGO2 expression in GC will help predict patient prognosis and the incidence of liver metastasis. |
| first_indexed | 2024-12-13T20:07:57Z |
| format | Article |
| id | doaj.art-bb21c97bf2804fd18632c3ba814eb339 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-13T20:07:57Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-bb21c97bf2804fd18632c3ba814eb3392022-12-21T23:32:58ZengBMCBMC Cancer1471-24072022-03-012211910.1186/s12885-022-09339-0The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patientsKeisuke Goto0Masaki Morimoto1Mitsuhiko Osaki2Akimitsu Tanio3Runa Izutsu4Yoshiyuki Fujiwara5Futoshi Okada6Division of Experimental Pathology, Faculty of Medicine, Tottori UniversityDepartment of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori UniversityDivision of Experimental Pathology, Faculty of Medicine, Tottori UniversityDepartment of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori UniversityDivision of Experimental Pathology, Faculty of Medicine, Tottori UniversityDepartment of Surgery, Division of Gastrointestinal and Pediatric Surgery, Faculty of Medicine, Tottori UniversityDivision of Experimental Pathology, Faculty of Medicine, Tottori UniversityAbstract Background Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour cell adhesion in adenocarcinomas; however, its importance in GC remains undetermined. Methods We analyzed AMIGO2 expression by immunohistochemistry using the specific monoclonal antibody for human AMIGO2 in 128 patients who underwent GC surgery to evaluate its relationship between various metastatic and clinical outcomes in GC. Results Immunohistochemistry revealed that AMIGO2 expression was an independent prognostic factor for overall survival, disease-specific survival, and liver metastasis in GC patients. Conclusions This study showed that AMIGO2 is induced in GC tissues and can mediate hepatic metastasis. Determining AMIGO2 expression in GC will help predict patient prognosis and the incidence of liver metastasis.https://doi.org/10.1186/s12885-022-09339-0AMIGO2AMIGOGastric cancerHepatic metastasis |
| spellingShingle | Keisuke Goto Masaki Morimoto Mitsuhiko Osaki Akimitsu Tanio Runa Izutsu Yoshiyuki Fujiwara Futoshi Okada The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients BMC Cancer AMIGO2 AMIGO Gastric cancer Hepatic metastasis |
| title | The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients |
| title_full | The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients |
| title_fullStr | The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients |
| title_full_unstemmed | The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients |
| title_short | The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients |
| title_sort | impact of amigo2 on prognosis and hepatic metastasis in gastric cancer patients |
| topic | AMIGO2 AMIGO Gastric cancer Hepatic metastasis |
| url | https://doi.org/10.1186/s12885-022-09339-0 |
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