High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters
Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-02-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000100008&lng=en&tlng=en |
| _version_ | 1797713507483910144 |
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| author | Ana Lúcia Souza Antunes Jéssica Weis Bonfanti Leandro Reus Rodrigues Perez Camille Cattani Ferreira Pinto Ana Lúcia Peixoto de Freitas Alexandre José Macedo Afonso Luis Barth |
| author_facet | Ana Lúcia Souza Antunes Jéssica Weis Bonfanti Leandro Reus Rodrigues Perez Camille Cattani Ferreira Pinto Ana Lúcia Peixoto de Freitas Alexandre José Macedo Afonso Luis Barth |
| author_sort | Ana Lúcia Souza Antunes |
| collection | DOAJ |
| description | Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection. |
| first_indexed | 2024-03-12T07:37:38Z |
| format | Article |
| id | doaj.art-bb231ef47fed411db03e8b856b7090ac |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:37:38Z |
| publishDate | 2011-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-bb231ef47fed411db03e8b856b7090ac2023-09-02T21:28:40ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-02-011061515510.1590/S0074-02762011000100008S0074-02762011000100008High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous cathetersAna Lúcia Souza Antunes0Jéssica Weis Bonfanti1Leandro Reus Rodrigues Perez2Camille Cattani Ferreira Pinto3Ana Lúcia Peixoto de Freitas4Alexandre José Macedo5Afonso Luis Barth6Faculdade de FarmáciaFaculdade de FarmáciaFaculdade de FarmáciaFaculdade de FarmáciaFaculdade de FarmáciaFaculdade de FarmáciaFaculdade de FarmáciaBiofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000100008&lng=en&tlng=enbiofilmvancomycinStaphylococcus spp |
| spellingShingle | Ana Lúcia Souza Antunes Jéssica Weis Bonfanti Leandro Reus Rodrigues Perez Camille Cattani Ferreira Pinto Ana Lúcia Peixoto de Freitas Alexandre José Macedo Afonso Luis Barth High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters Memorias do Instituto Oswaldo Cruz biofilm vancomycin Staphylococcus spp |
| title | High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
| title_full | High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
| title_fullStr | High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
| title_full_unstemmed | High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
| title_short | High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
| title_sort | high vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters |
| topic | biofilm vancomycin Staphylococcus spp |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000100008&lng=en&tlng=en |
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