Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism

Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism

Abstract Background Many children and young people with autism spectrum disorder (ASD) display touch defensiveness or avoidance (hypersensitivity), or engage in sensory seeking by touching people or objects (hyposensitivity). Abnormal sensory responses have also been noticed in mice lacking ASD-asso...

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Bibliographic Details
Main Authors: Xue Li, Shishuai Hao, Shimin Zou, Xiaomeng Tu, Weixi Kong, Tian Jiang, Jie-Guang Chen
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Molecular Autism
Subjects:
Autism
Tactile
Barrel cortex
Thalamocortical
c-Fos
Spines
Online Access:https://doi.org/10.1186/s13229-023-00567-0

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