Treating the Different Phenotypes of Behçet's Syndrome
Behçet's syndrome (BS) is a multisystemic vasculitis, characterized by different clinical involvements, including mucocutaneous, ocular, vascular, neurological, and gastrointestinal manifestations. Based on this heterogeneity, BS can be hardly considered as a single clinical entity. Growing evi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02830/full |
| _version_ | 1818527444532985856 |
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| author | Alessandra Bettiol Alessandra Bettiol Gulen Hatemi Lorenzo Vannozzi Alessandro Barilaro Domenico Prisco Giacomo Emmi |
| author_facet | Alessandra Bettiol Alessandra Bettiol Gulen Hatemi Lorenzo Vannozzi Alessandro Barilaro Domenico Prisco Giacomo Emmi |
| author_sort | Alessandra Bettiol |
| collection | DOAJ |
| description | Behçet's syndrome (BS) is a multisystemic vasculitis, characterized by different clinical involvements, including mucocutaneous, ocular, vascular, neurological, and gastrointestinal manifestations. Based on this heterogeneity, BS can be hardly considered as a single clinical entity. Growing evidence supports that, within BS, different phenotypes, characterized by clusters of co-existing involvements, can be distinguished. Namely, three major BS phenotypes have been reported: (a) the mucocutaneous and articular phenotype, (b) the extra-parenchymal neurological and peripheral vascular phenotype, and (c) the parenchymal neurological and ocular phenotype. To date, guidelines for the management of BS have been focused on the pharmacological treatment of each specific BS manifestation. However, tailoring the treatments on patient's specific phenotype, rather than on single disease manifestation, could represent a valid strategy for a personalized therapeutic approach to BS. In the present literature review, we summarize current evidence on the pharmacological treatments for the first-, second-, and third-line treatment of the major BS phenotypes. |
| first_indexed | 2024-12-11T06:36:15Z |
| format | Article |
| id | doaj.art-bb249ba736884a75b996431bdd1e4947 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T06:36:15Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-bb249ba736884a75b996431bdd1e49472022-12-22T01:17:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-12-011010.3389/fimmu.2019.02830490693Treating the Different Phenotypes of Behçet's SyndromeAlessandra Bettiol0Alessandra Bettiol1Gulen Hatemi2Lorenzo Vannozzi3Alessandro Barilaro4Domenico Prisco5Giacomo Emmi6Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, ItalyDivision of Rheumatology, Department of Internal Medicine, Istanbul University–Cerrahpaşa, Istanbul, TurkeyEye Clinic, Careggi Teaching Hospital, University of Florence, Florence, ItalyDepartment of Neurology 2 and Multiple Sclerosis Regional Referral Centre, Careggi University Hospital, Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyBehçet's syndrome (BS) is a multisystemic vasculitis, characterized by different clinical involvements, including mucocutaneous, ocular, vascular, neurological, and gastrointestinal manifestations. Based on this heterogeneity, BS can be hardly considered as a single clinical entity. Growing evidence supports that, within BS, different phenotypes, characterized by clusters of co-existing involvements, can be distinguished. Namely, three major BS phenotypes have been reported: (a) the mucocutaneous and articular phenotype, (b) the extra-parenchymal neurological and peripheral vascular phenotype, and (c) the parenchymal neurological and ocular phenotype. To date, guidelines for the management of BS have been focused on the pharmacological treatment of each specific BS manifestation. However, tailoring the treatments on patient's specific phenotype, rather than on single disease manifestation, could represent a valid strategy for a personalized therapeutic approach to BS. In the present literature review, we summarize current evidence on the pharmacological treatments for the first-, second-, and third-line treatment of the major BS phenotypes.https://www.frontiersin.org/article/10.3389/fimmu.2019.02830/fullBehçet's syndromephenotypescluster analysisanti-TNF-αDMARDs |
| spellingShingle | Alessandra Bettiol Alessandra Bettiol Gulen Hatemi Lorenzo Vannozzi Alessandro Barilaro Domenico Prisco Giacomo Emmi Treating the Different Phenotypes of Behçet's Syndrome Frontiers in Immunology Behçet's syndrome phenotypes cluster analysis anti-TNF-α DMARDs |
| title | Treating the Different Phenotypes of Behçet's Syndrome |
| title_full | Treating the Different Phenotypes of Behçet's Syndrome |
| title_fullStr | Treating the Different Phenotypes of Behçet's Syndrome |
| title_full_unstemmed | Treating the Different Phenotypes of Behçet's Syndrome |
| title_short | Treating the Different Phenotypes of Behçet's Syndrome |
| title_sort | treating the different phenotypes of behcet s syndrome |
| topic | Behçet's syndrome phenotypes cluster analysis anti-TNF-α DMARDs |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02830/full |
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