The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants
BackgroundAdiposity and adipokines are closely associated with obesity-related metabolic abnormalities, but little is known regarding whether abdominal obesity is linked to type 2 diabetes mellitus (T2DM) through circulating adiponectin levels. Thus, this large-population–based study was designed to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1327716/full |
| _version_ | 1827345162784735232 |
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| author | Lingjie He Wenting Xuan Dixing Liu Jiana Zhong Huijin Luo Han Cui Xiuwei Zhang Weikun Chen |
| author_facet | Lingjie He Wenting Xuan Dixing Liu Jiana Zhong Huijin Luo Han Cui Xiuwei Zhang Weikun Chen |
| author_sort | Lingjie He |
| collection | DOAJ |
| description | BackgroundAdiposity and adipokines are closely associated with obesity-related metabolic abnormalities, but little is known regarding whether abdominal obesity is linked to type 2 diabetes mellitus (T2DM) through circulating adiponectin levels. Thus, this large-population–based study was designed to investigate the mediating effect of adiponectin in the relationship between abdominal obesity and T2DM.MethodsA total of 232,438 adults who lived in Dongguan, Guangdong Province, China, were enrolled in the present study. The circulating adiponectin concentrations were measured using latex-enhanced immunoturbidimetric assay. The association between circulating adiponectin and other clinical parameters was detected by Spearman’s correlation analysis. Restricted cubic spline (RCS) regression was also used to address the non-linearity of the relationship between waist circumference and diabetes. Mediation analyses of circulating adiponectin were conducted using linear and logistic regression.ResultsSubjects with abdominal obesity had lower levels of circulating adiponectin (P < 0.001). The circulating adiponectin value was inversely related to BMI (r = −0.370, P < 0.001), waist circumference (r = −0.361, P < 0.001), and fasting plasma glucose (r = −0.221, P < 0.001). The RCS plot showed a non-linear relation linking waist circumference with T2DM (P for non-linearity < 0.001). Patients with abdominal obesity presented 2.062 times higher odds of T2DM in comparison with those with non-abdominal obesity (odds ratio, 2.062; 95% confidence interval, 1.969–2.161) after adjusting for confounders. In the mediation analyses, the circulating adiponectin mediated the association between abdominal obesity and T2DM, with a mediation effect of 41.02% after adjustments. The above results were consistent in both men and women.ConclusionThe relationship between abdominal obesity and T2DM is mediated through circulating adiponectin level in adults, suggesting that circulating adiponectin might be a potential predictor for controlling the adverse progression from adiposity to T2DM. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T23:02:25Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-bb26ec8cc7204f93b6cd1816eb57588f2024-02-22T13:19:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.13277161327716The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participantsLingjie He0Wenting Xuan1Dixing Liu2Jiana Zhong3Huijin Luo4Han Cui5Xiuwei Zhang6Weikun Chen7Department of Endocrinology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, ChinaDepartment of Endocrinology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, ChinaDepartment of Endocrinology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, ChinaDepartment of Endocrinology, Dongguan Affiliated Hospital of Jinan University, Binhaiwan Central Hospital of Dongguan, Dongguan, ChinaDepartment of Endocrinology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, ChinaDepartment of Endocrinology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, ChinaDepartment of Endocrinology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, ChinaDepartment of Endocrinology, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, ChinaBackgroundAdiposity and adipokines are closely associated with obesity-related metabolic abnormalities, but little is known regarding whether abdominal obesity is linked to type 2 diabetes mellitus (T2DM) through circulating adiponectin levels. Thus, this large-population–based study was designed to investigate the mediating effect of adiponectin in the relationship between abdominal obesity and T2DM.MethodsA total of 232,438 adults who lived in Dongguan, Guangdong Province, China, were enrolled in the present study. The circulating adiponectin concentrations were measured using latex-enhanced immunoturbidimetric assay. The association between circulating adiponectin and other clinical parameters was detected by Spearman’s correlation analysis. Restricted cubic spline (RCS) regression was also used to address the non-linearity of the relationship between waist circumference and diabetes. Mediation analyses of circulating adiponectin were conducted using linear and logistic regression.ResultsSubjects with abdominal obesity had lower levels of circulating adiponectin (P < 0.001). The circulating adiponectin value was inversely related to BMI (r = −0.370, P < 0.001), waist circumference (r = −0.361, P < 0.001), and fasting plasma glucose (r = −0.221, P < 0.001). The RCS plot showed a non-linear relation linking waist circumference with T2DM (P for non-linearity < 0.001). Patients with abdominal obesity presented 2.062 times higher odds of T2DM in comparison with those with non-abdominal obesity (odds ratio, 2.062; 95% confidence interval, 1.969–2.161) after adjusting for confounders. In the mediation analyses, the circulating adiponectin mediated the association between abdominal obesity and T2DM, with a mediation effect of 41.02% after adjustments. The above results were consistent in both men and women.ConclusionThe relationship between abdominal obesity and T2DM is mediated through circulating adiponectin level in adults, suggesting that circulating adiponectin might be a potential predictor for controlling the adverse progression from adiposity to T2DM.https://www.frontiersin.org/articles/10.3389/fendo.2024.1327716/fulladiponectinadiposityabdominal obesitytype 2 diabetes mellitusmediation analysis |
| spellingShingle | Lingjie He Wenting Xuan Dixing Liu Jiana Zhong Huijin Luo Han Cui Xiuwei Zhang Weikun Chen The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants Frontiers in Endocrinology adiponectin adiposity abdominal obesity type 2 diabetes mellitus mediation analysis |
| title | The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants |
| title_full | The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants |
| title_fullStr | The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants |
| title_full_unstemmed | The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants |
| title_short | The role of adiponectin in the association between abdominal obesity and type 2 diabetes: a mediation analysis among 232,438 Chinese participants |
| title_sort | role of adiponectin in the association between abdominal obesity and type 2 diabetes a mediation analysis among 232 438 chinese participants |
| topic | adiponectin adiposity abdominal obesity type 2 diabetes mellitus mediation analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1327716/full |
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