BCR-ABL affects STAT5A and STAT5B differentially.
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene transcription. Hematopoietic cells express two highly conserved STAT5-isoforms (STAT5A/STAT5B), and STAT5 is directly activated by JAK2 downstream of s...
المؤلفون الرئيسيون: | , , , , , , , , , |
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التنسيق: | مقال |
اللغة: | English |
منشور في: |
Public Library of Science (PLoS)
2014-01-01
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سلاسل: | PLoS ONE |
الوصول للمادة أونلاين: | http://europepmc.org/articles/PMC4023949?pdf=render |