Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China.
BACKGROUND: Anaplastic thyroid carcinoma (ATC), a highly aggressive malignancy, has a poor prognosis, and the consensus on the most effective treatment is needed. METHODS: Clinical data from all ATC patients treated in our institution over a 30-year period (between May 1980 and May 2010) were analyz...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3818277?pdf=render |
| _version_ | 1828859369622601728 |
|---|---|
| author | Chuanzheng Sun Qiuli Li Zedong Hu Jiehua He Chao Li Guojun Li Xiaofeng Tao Ankui Yang |
| author_facet | Chuanzheng Sun Qiuli Li Zedong Hu Jiehua He Chao Li Guojun Li Xiaofeng Tao Ankui Yang |
| author_sort | Chuanzheng Sun |
| collection | DOAJ |
| description | BACKGROUND: Anaplastic thyroid carcinoma (ATC), a highly aggressive malignancy, has a poor prognosis, and the consensus on the most effective treatment is needed. METHODS: Clinical data from all ATC patients treated in our institution over a 30-year period (between May 1980 and May 2010) were analyzed retrospectively with regard to mortality and survival rates (Kaplan-Meier). Multivariate analysis was performed using a Cox proportional hazards model. RESULTS: Sixty cases were analyzed. The overall 1- and 3-year survival rates were 35.0% and 22.9%, respectively. Univariate analysis showed that the best prognosis was seen in patients younger than 55 years, those without distant metastases, those with white blood cell (WBC) counts < 10.0 × 10(9)/L or blood platelet (PLT) counts < 300.0 × 10(9)/L at presentation, those who did not receive chemotherapy, and those who received radiotherapy doses ≥ 40 Gy or underwent surgery plus postoperative radiotherapy. According to multivariate analysis, the WBC count at first presentation and the type of therapeutic regimen independently influenced survival. CONCLUSIONS: We found that the elevated peripheral PLT count may be an adverse prognostic factor of ATC patients. The prognosis for ATC is especially poor for patients with distant metastasis, a WBC count ≥ 10.0×10(9)/L, a PLT count ≥ 300.0 × 10(9)/L, or age ≥ 55 years. WBC count at presentation and surgery with or without postoperative radiotherapy independently influenced the prognosis. Intensive treatment combining surgery with postoperative radiotherapy is recommended for ATC patients with stage IVA/B disease. |
| first_indexed | 2024-12-13T02:17:16Z |
| format | Article |
| id | doaj.art-bb2b85213d1f4cf5b23a3560688b7e8d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:17:16Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-bb2b85213d1f4cf5b23a3560688b7e8d2022-12-22T00:02:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e8001110.1371/journal.pone.0080011Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China.Chuanzheng SunQiuli LiZedong HuJiehua HeChao LiGuojun LiXiaofeng TaoAnkui YangBACKGROUND: Anaplastic thyroid carcinoma (ATC), a highly aggressive malignancy, has a poor prognosis, and the consensus on the most effective treatment is needed. METHODS: Clinical data from all ATC patients treated in our institution over a 30-year period (between May 1980 and May 2010) were analyzed retrospectively with regard to mortality and survival rates (Kaplan-Meier). Multivariate analysis was performed using a Cox proportional hazards model. RESULTS: Sixty cases were analyzed. The overall 1- and 3-year survival rates were 35.0% and 22.9%, respectively. Univariate analysis showed that the best prognosis was seen in patients younger than 55 years, those without distant metastases, those with white blood cell (WBC) counts < 10.0 × 10(9)/L or blood platelet (PLT) counts < 300.0 × 10(9)/L at presentation, those who did not receive chemotherapy, and those who received radiotherapy doses ≥ 40 Gy or underwent surgery plus postoperative radiotherapy. According to multivariate analysis, the WBC count at first presentation and the type of therapeutic regimen independently influenced survival. CONCLUSIONS: We found that the elevated peripheral PLT count may be an adverse prognostic factor of ATC patients. The prognosis for ATC is especially poor for patients with distant metastasis, a WBC count ≥ 10.0×10(9)/L, a PLT count ≥ 300.0 × 10(9)/L, or age ≥ 55 years. WBC count at presentation and surgery with or without postoperative radiotherapy independently influenced the prognosis. Intensive treatment combining surgery with postoperative radiotherapy is recommended for ATC patients with stage IVA/B disease.http://europepmc.org/articles/PMC3818277?pdf=render |
| spellingShingle | Chuanzheng Sun Qiuli Li Zedong Hu Jiehua He Chao Li Guojun Li Xiaofeng Tao Ankui Yang Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China. PLoS ONE |
| title | Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China. |
| title_full | Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China. |
| title_fullStr | Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China. |
| title_full_unstemmed | Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China. |
| title_short | Treatment and prognosis of anaplastic thyroid carcinoma: experience from a single institution in China. |
| title_sort | treatment and prognosis of anaplastic thyroid carcinoma experience from a single institution in china |
| url | http://europepmc.org/articles/PMC3818277?pdf=render |
| work_keys_str_mv | AT chuanzhengsun treatmentandprognosisofanaplasticthyroidcarcinomaexperiencefromasingleinstitutioninchina AT qiulili treatmentandprognosisofanaplasticthyroidcarcinomaexperiencefromasingleinstitutioninchina AT zedonghu treatmentandprognosisofanaplasticthyroidcarcinomaexperiencefromasingleinstitutioninchina AT jiehuahe treatmentandprognosisofanaplasticthyroidcarcinomaexperiencefromasingleinstitutioninchina AT chaoli treatmentandprognosisofanaplasticthyroidcarcinomaexperiencefromasingleinstitutioninchina AT guojunli treatmentandprognosisofanaplasticthyroidcarcinomaexperiencefromasingleinstitutioninchina AT xiaofengtao treatmentandprognosisofanaplasticthyroidcarcinomaexperiencefromasingleinstitutioninchina AT ankuiyang treatmentandprognosisofanaplasticthyroidcarcinomaexperiencefromasingleinstitutioninchina |