Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial
BackgroundHydroxyethyl starch (HES) solutions are used as plasma expanders for correcting hypovolemia, but can lead to impaired coagulation. We evaluated the changes in hematological and hemostatic profiles with three types of HES.MethodsPatients were randomized to receive volume replacement with 10...
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Korean Society of Anesthesiologists
2015-08-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kjae-68-364.pdf |
| _version_ | 1818606015884558336 |
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| author | Hyun-Jung Shin Hyo-Seok Na Young-Tae Jeon Gwan Woo Lee Sang-Hwan Do |
| author_facet | Hyun-Jung Shin Hyo-Seok Na Young-Tae Jeon Gwan Woo Lee Sang-Hwan Do |
| author_sort | Hyun-Jung Shin |
| collection | DOAJ |
| description | BackgroundHydroxyethyl starch (HES) solutions are used as plasma expanders for correcting hypovolemia, but can lead to impaired coagulation. We evaluated the changes in hematological and hemostatic profiles with three types of HES.MethodsPatients were randomized to receive volume replacement with 10% pentastarch 260/0.45 in 0.9% saline (Group-PEN, n = 25), 6% tetrastarch 130/0.4 in 0.9% saline (Group-TETS, n = 25), or 6% tetrastarch 130/0.4 in a balanced electrolyte solution (Group-TETB, n = 25). Coagulation was assessed using rotational thromboelastometry (ROTEM®) and other laboratory tests were performed, including measurements of hematological and hemostatic parameters and electrolytes.ResultsPost-operative ROTEM® parameters changed toward hypocoagulable states in all groups. The post-operative parameters of EXTEM and FIBTEM were more impaired in Group-PEN than in Group-TETB. The percentage change in INTEM clot formation time (P = 0.004) and α-angle (P = 0.003) were smaller in Group-TETS and Group-TETB than in Group-PEN. The percentage change in the FIBTEM maximum clot firmness was greatest in Group-PEN (P = 0.011). The international normalized ratio of prothrombin time (P < 0.001) and the activated partial thromboplastin time (P < 0.001) were significantly prolonged in Group-PEN compared to those of Group-TETB.ConclusionsThe 6% HES 130/0.4 in a balanced electrolyte solution seemed to have less of an impact on blood coagulation than the 10% HES 260/0.45. No differences in hemostatic profile were observed between the balanced electrolyte and saline-based 6% HES 130/0.4. |
| first_indexed | 2024-12-16T14:04:08Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-16T14:04:08Z |
| publishDate | 2015-08-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-bb2bb53afeb646f2a53129342bafb3352022-12-21T22:28:58ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632015-08-0168436437210.4097/kjae.2015.68.4.3648088Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trialHyun-Jung Shin0Hyo-Seok Na1Young-Tae Jeon2Gwan Woo Lee3Sang-Hwan Do4Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Anesthesiology and Pain Medicine, Dankook University Hospital, Cheonan, Korea.Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.BackgroundHydroxyethyl starch (HES) solutions are used as plasma expanders for correcting hypovolemia, but can lead to impaired coagulation. We evaluated the changes in hematological and hemostatic profiles with three types of HES.MethodsPatients were randomized to receive volume replacement with 10% pentastarch 260/0.45 in 0.9% saline (Group-PEN, n = 25), 6% tetrastarch 130/0.4 in 0.9% saline (Group-TETS, n = 25), or 6% tetrastarch 130/0.4 in a balanced electrolyte solution (Group-TETB, n = 25). Coagulation was assessed using rotational thromboelastometry (ROTEM®) and other laboratory tests were performed, including measurements of hematological and hemostatic parameters and electrolytes.ResultsPost-operative ROTEM® parameters changed toward hypocoagulable states in all groups. The post-operative parameters of EXTEM and FIBTEM were more impaired in Group-PEN than in Group-TETB. The percentage change in INTEM clot formation time (P = 0.004) and α-angle (P = 0.003) were smaller in Group-TETS and Group-TETB than in Group-PEN. The percentage change in the FIBTEM maximum clot firmness was greatest in Group-PEN (P = 0.011). The international normalized ratio of prothrombin time (P < 0.001) and the activated partial thromboplastin time (P < 0.001) were significantly prolonged in Group-PEN compared to those of Group-TETB.ConclusionsThe 6% HES 130/0.4 in a balanced electrolyte solution seemed to have less of an impact on blood coagulation than the 10% HES 260/0.45. No differences in hemostatic profile were observed between the balanced electrolyte and saline-based 6% HES 130/0.4.http://ekja.org/upload/pdf/kjae-68-364.pdfblood coagulationhydroxyethyl starchrotational thromboelastometry |
| spellingShingle | Hyun-Jung Shin Hyo-Seok Na Young-Tae Jeon Gwan Woo Lee Sang-Hwan Do Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial Korean Journal of Anesthesiology blood coagulation hydroxyethyl starch rotational thromboelastometry |
| title | Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial |
| title_full | Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial |
| title_fullStr | Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial |
| title_full_unstemmed | Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial |
| title_short | Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial |
| title_sort | changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty comparison between pentastarch and tetrastarches a randomized trial |
| topic | blood coagulation hydroxyethyl starch rotational thromboelastometry |
| url | http://ekja.org/upload/pdf/kjae-68-364.pdf |
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