Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats
Anacardium occidentale L. (Anacardiaceae) is used in South Cameroon as well as in other tropical countries by traditional practitioners as a folk remedy for treatment of diabetes mellitus. We demonstrated the antidiabetic potential of the plant extracts in n-streptozotocin diabetic rats. The aim of...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Journal of Traditional and Complementary Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411016302899 |
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| author | Y.S. Jaiswal P.A. Tatke S.Y. Gabhe A.B. Vaidya |
| author_facet | Y.S. Jaiswal P.A. Tatke S.Y. Gabhe A.B. Vaidya |
| author_sort | Y.S. Jaiswal |
| collection | DOAJ |
| description | Anacardium occidentale L. (Anacardiaceae) is used in South Cameroon as well as in other tropical countries by traditional practitioners as a folk remedy for treatment of diabetes mellitus. We demonstrated the antidiabetic potential of the plant extracts in n-streptozotocin diabetic rats. The aim of the current study was to investigate the antidiabetic effects of ethanol extract of leaves of A. occidentale on neonatal streptozotocin diabetic rats.
Two day old neonates were injected with 100 mg/kg of streptozotocin. At the end of the experimental period of 30 days, reduction in the fasting blood glucose levels, serum insulin, glycated hemoglobin levels, serum lipid parameters, and renal function biomarkers were estimated in the control and treated rats. Histopathological examination of liver, kidney and pancreas were also carried out.
On administration of 100 mg/kg of plant extract, blood glucose levels of the rats showed 8.01% and 19.25% decrease in the fasting blood glucose levels on day 15 and day 30, respectively. The administration of extract showed that the effects of extract treatment are comparable to treatment with the standard drug Pioglitazone.
These results demonstrate significant antidiabetic potential of the ethanol extract of leaves of A. occidentale, justifying the use of plant in the indigenous system of medicine. Further studies for investigating the specific compound(s) responsible for such beneficial role in diabetes would open new outlook in the therapy of type 2 diabetes. |
| first_indexed | 2024-04-13T11:27:51Z |
| format | Article |
| id | doaj.art-bb2ef7c75b1e4925905c29d6d2d407f2 |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-04-13T11:27:51Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-bb2ef7c75b1e4925905c29d6d2d407f22022-12-22T02:48:38ZengElsevierJournal of Traditional and Complementary Medicine2225-41102017-10-017442142710.1016/j.jtcme.2016.11.007Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic ratsY.S. Jaiswal0P.A. Tatke1S.Y. Gabhe2A.B. Vaidya3C.U.Shah College of Pharmacy, S.N.D.T Women's University, Mumbai 400049, IndiaC.U.Shah College of Pharmacy, S.N.D.T Women's University, Mumbai 400049, IndiaC.U.Shah College of Pharmacy, S.N.D.T Women's University, Mumbai 400049, IndiaICMR Advanced Centre of Reverse Pharmacology in Traditional Medicine, Kasturba Health Society, Vile Parle-(W), Mumbai 400 056, IndiaAnacardium occidentale L. (Anacardiaceae) is used in South Cameroon as well as in other tropical countries by traditional practitioners as a folk remedy for treatment of diabetes mellitus. We demonstrated the antidiabetic potential of the plant extracts in n-streptozotocin diabetic rats. The aim of the current study was to investigate the antidiabetic effects of ethanol extract of leaves of A. occidentale on neonatal streptozotocin diabetic rats. Two day old neonates were injected with 100 mg/kg of streptozotocin. At the end of the experimental period of 30 days, reduction in the fasting blood glucose levels, serum insulin, glycated hemoglobin levels, serum lipid parameters, and renal function biomarkers were estimated in the control and treated rats. Histopathological examination of liver, kidney and pancreas were also carried out. On administration of 100 mg/kg of plant extract, blood glucose levels of the rats showed 8.01% and 19.25% decrease in the fasting blood glucose levels on day 15 and day 30, respectively. The administration of extract showed that the effects of extract treatment are comparable to treatment with the standard drug Pioglitazone. These results demonstrate significant antidiabetic potential of the ethanol extract of leaves of A. occidentale, justifying the use of plant in the indigenous system of medicine. Further studies for investigating the specific compound(s) responsible for such beneficial role in diabetes would open new outlook in the therapy of type 2 diabetes.http://www.sciencedirect.com/science/article/pii/S2225411016302899Anacardium occidentaleNeonatal-induced diabetic ratsType 2 diabetesStreptozotocinLeaves |
| spellingShingle | Y.S. Jaiswal P.A. Tatke S.Y. Gabhe A.B. Vaidya Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats Journal of Traditional and Complementary Medicine Anacardium occidentale Neonatal-induced diabetic rats Type 2 diabetes Streptozotocin Leaves |
| title | Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats |
| title_full | Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats |
| title_fullStr | Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats |
| title_full_unstemmed | Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats |
| title_short | Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats |
| title_sort | antidiabetic activity of extracts of anacardium occidentale linn leaves on n streptozotocin diabetic rats |
| topic | Anacardium occidentale Neonatal-induced diabetic rats Type 2 diabetes Streptozotocin Leaves |
| url | http://www.sciencedirect.com/science/article/pii/S2225411016302899 |
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