Presence of HLA-DQ2 and HLA-DQ8 /DR4 celiac disease predisposing alleles in tested group of patients in Bosnia and Herzegovina
Celiac disease (CD) is an autoimmune disease characterized by gluten intolerance. The main cause of this immune - mediated enteropathy is gluten, a protein mainly present in wheat, rye, barley and spelt. The predisposition to celiac disease is determined by HLA class II genes encoding MHC II hetero...
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| Format: | Article |
| Language: | English |
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University of Sarajevo, Institute for Genetic Engineering and Biotechnology
2023-12-01
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| Series: | Genetics & Applications |
| Subjects: | |
| Online Access: | https://genapp.ba/editions/index.php/journal/article/view/194 |
| _version_ | 1827580472001036288 |
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| author | Tea Bećirević Selma Kozarić Ammar Đugum Selen Čović |
| author_facet | Tea Bećirević Selma Kozarić Ammar Đugum Selen Čović |
| author_sort | Tea Bećirević |
| collection | DOAJ |
| description |
Celiac disease (CD) is an autoimmune disease characterized by gluten intolerance. The main cause of this immune - mediated enteropathy is gluten, a protein mainly present in wheat, rye, barley and spelt. The predisposition to celiac disease is determined by HLA class II genes encoding MHC II heterodimer molecules, more specifically HLA-DQ2 and HLA-DQ8. Up to date the exact number of people suffering from celiac disease in Bosnia and Herzegovina is still not known because there is no public registry for this disease. The aim of this study was to evaluate the HLA-DQ2 and HLA-DQ8/DR4 presence in tested group of patients (n = 23) referred to Polyclinic Atrijum in Sarajevo in period from August 2022. to August 2023. HLA-DQ2 and DQ8/DR4 allele identification was performed using Real-time PCR technique. According to the obtained results a total of 26% (n=6) of tested patients were positive for HLA-DQ2 and HLA-DQ8/DR4 alleles. Two of the patients were positive for HLA-DQ2 alleles and four patients were positive for HLA-DQ8/DR4 alleles. To our knowledge this is the first study evaluating the presence of HLA-DQ2 and HLA-DQ8 genotypes in tested population in Bosnia and Herzegovina.
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| first_indexed | 2024-03-08T22:20:34Z |
| format | Article |
| id | doaj.art-bb2f050b21424f05ae5a4a42ca632187 |
| institution | Directory Open Access Journal |
| issn | 2566-2937 2566-431X |
| language | English |
| last_indexed | 2024-03-08T22:20:34Z |
| publishDate | 2023-12-01 |
| publisher | University of Sarajevo, Institute for Genetic Engineering and Biotechnology |
| record_format | Article |
| series | Genetics & Applications |
| spelling | doaj.art-bb2f050b21424f05ae5a4a42ca6321872023-12-18T13:35:52ZengUniversity of Sarajevo, Institute for Genetic Engineering and BiotechnologyGenetics & Applications2566-29372566-431X2023-12-017210.31383/ga.vol7iss2ga06Presence of HLA-DQ2 and HLA-DQ8 /DR4 celiac disease predisposing alleles in tested group of patients in Bosnia and HerzegovinaTea Bećirević0Selma Kozarić1Ammar Đugum2Selen Čović3Atrijum Polyclinic, Sarajevo, Bosnia and Herzegovina; Faculty of Natural Sciences and Mathematics, Sarajevo, Bosnia and HerzegovinaAtrijum Polyclinic, Sarajevo, Bosnia and Herzegovina; International University of Sarajevo, Sarajevo, Bosnia and HerzegovinaAtrijum Polyclinic, Sarajevo, Bosnia and HerzegovinaAtrijum Polyclinic, Sarajevo, Bosnia and Herzegovina Celiac disease (CD) is an autoimmune disease characterized by gluten intolerance. The main cause of this immune - mediated enteropathy is gluten, a protein mainly present in wheat, rye, barley and spelt. The predisposition to celiac disease is determined by HLA class II genes encoding MHC II heterodimer molecules, more specifically HLA-DQ2 and HLA-DQ8. Up to date the exact number of people suffering from celiac disease in Bosnia and Herzegovina is still not known because there is no public registry for this disease. The aim of this study was to evaluate the HLA-DQ2 and HLA-DQ8/DR4 presence in tested group of patients (n = 23) referred to Polyclinic Atrijum in Sarajevo in period from August 2022. to August 2023. HLA-DQ2 and DQ8/DR4 allele identification was performed using Real-time PCR technique. According to the obtained results a total of 26% (n=6) of tested patients were positive for HLA-DQ2 and HLA-DQ8/DR4 alleles. Two of the patients were positive for HLA-DQ2 alleles and four patients were positive for HLA-DQ8/DR4 alleles. To our knowledge this is the first study evaluating the presence of HLA-DQ2 and HLA-DQ8 genotypes in tested population in Bosnia and Herzegovina. https://genapp.ba/editions/index.php/journal/article/view/194celiac diseaseHLA-DQ2HLA-DQ8 |
| spellingShingle | Tea Bećirević Selma Kozarić Ammar Đugum Selen Čović Presence of HLA-DQ2 and HLA-DQ8 /DR4 celiac disease predisposing alleles in tested group of patients in Bosnia and Herzegovina Genetics & Applications celiac disease HLA-DQ2 HLA-DQ8 |
| title | Presence of HLA-DQ2 and HLA-DQ8 /DR4 celiac disease predisposing alleles in tested group of patients in Bosnia and Herzegovina |
| title_full | Presence of HLA-DQ2 and HLA-DQ8 /DR4 celiac disease predisposing alleles in tested group of patients in Bosnia and Herzegovina |
| title_fullStr | Presence of HLA-DQ2 and HLA-DQ8 /DR4 celiac disease predisposing alleles in tested group of patients in Bosnia and Herzegovina |
| title_full_unstemmed | Presence of HLA-DQ2 and HLA-DQ8 /DR4 celiac disease predisposing alleles in tested group of patients in Bosnia and Herzegovina |
| title_short | Presence of HLA-DQ2 and HLA-DQ8 /DR4 celiac disease predisposing alleles in tested group of patients in Bosnia and Herzegovina |
| title_sort | presence of hla dq2 and hla dq8 dr4 celiac disease predisposing alleles in tested group of patients in bosnia and herzegovina |
| topic | celiac disease HLA-DQ2 HLA-DQ8 |
| url | https://genapp.ba/editions/index.php/journal/article/view/194 |
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