Modeling the Architecture of Depolymerase-Containing Receptor Binding Proteins in Klebsiella Phages

Modeling the Architecture of Depolymerase-Containing Receptor Binding Proteins in Klebsiella Phages

Klebsiella pneumoniae carries a thick polysaccharide capsule. This highly variable chemical structure plays an important role in its virulence. Many Klebsiella bacteriophages recognize this capsule with a receptor binding protein (RBP) that contains a depolymerase domain. This domain degrades the ca...

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Bibliographic Details
Main Authors: Agnieszka Latka, Petr G. Leiman, Zuzanna Drulis-Kawa, Yves Briers
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Microbiology
Subjects:
horizontal transfer
tail fiber genes
receptor binding protein
phage evolution
depolymerase
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02649/full

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