Zebrafish Larvae as a Behavioral Model in Neuropharmacology
Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark conditions, following the development of a swim bladder at 4 days post fertilization. This swimming behavior is increasingly employed in the screening of neuroactive drugs. The recent emergence of high-throu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-03-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/7/1/23 |
| _version_ | 1819205277344333824 |
|---|---|
| author | Ram Manohar Basnet Daniela Zizioli Somrat Taweedet Dario Finazzi Maurizio Memo |
| author_facet | Ram Manohar Basnet Daniela Zizioli Somrat Taweedet Dario Finazzi Maurizio Memo |
| author_sort | Ram Manohar Basnet |
| collection | DOAJ |
| description | Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark conditions, following the development of a swim bladder at 4 days post fertilization. This swimming behavior is increasingly employed in the screening of neuroactive drugs. The recent emergence of high-throughput techniques for the automatic tracking of zebrafish larvae has further allowed an objective and efficient way of finding subtle behavioral changes that could go unnoticed during manual observations. This review highlights the use of zebrafish larvae as a high-throughput behavioral model for the screening of neuroactive compounds. We describe, in brief, the behavior repertoire of zebrafish larvae. Then, we focus on the utilization of light-dark locomotion test in identifying and screening of neuroactive compounds. |
| first_indexed | 2024-12-23T04:49:09Z |
| format | Article |
| id | doaj.art-bb31040142e6490a8286ddf77fb3e7e0 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-12-23T04:49:09Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-bb31040142e6490a8286ddf77fb3e7e02022-12-21T17:59:31ZengMDPI AGBiomedicines2227-90592019-03-01712310.3390/biomedicines7010023biomedicines7010023Zebrafish Larvae as a Behavioral Model in NeuropharmacologyRam Manohar Basnet0Daniela Zizioli1Somrat Taweedet2Dario Finazzi3Maurizio Memo4Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, ItalyZebrafish larvae show a clear and distinct pattern of swimming in response to light and dark conditions, following the development of a swim bladder at 4 days post fertilization. This swimming behavior is increasingly employed in the screening of neuroactive drugs. The recent emergence of high-throughput techniques for the automatic tracking of zebrafish larvae has further allowed an objective and efficient way of finding subtle behavioral changes that could go unnoticed during manual observations. This review highlights the use of zebrafish larvae as a high-throughput behavioral model for the screening of neuroactive compounds. We describe, in brief, the behavior repertoire of zebrafish larvae. Then, we focus on the utilization of light-dark locomotion test in identifying and screening of neuroactive compounds.https://www.mdpi.com/2227-9059/7/1/23zebrafish larvaebehaviorneuropharmacologyhigh-throughput screeningneuroactive drugslight-dark test |
| spellingShingle | Ram Manohar Basnet Daniela Zizioli Somrat Taweedet Dario Finazzi Maurizio Memo Zebrafish Larvae as a Behavioral Model in Neuropharmacology Biomedicines zebrafish larvae behavior neuropharmacology high-throughput screening neuroactive drugs light-dark test |
| title | Zebrafish Larvae as a Behavioral Model in Neuropharmacology |
| title_full | Zebrafish Larvae as a Behavioral Model in Neuropharmacology |
| title_fullStr | Zebrafish Larvae as a Behavioral Model in Neuropharmacology |
| title_full_unstemmed | Zebrafish Larvae as a Behavioral Model in Neuropharmacology |
| title_short | Zebrafish Larvae as a Behavioral Model in Neuropharmacology |
| title_sort | zebrafish larvae as a behavioral model in neuropharmacology |
| topic | zebrafish larvae behavior neuropharmacology high-throughput screening neuroactive drugs light-dark test |
| url | https://www.mdpi.com/2227-9059/7/1/23 |
| work_keys_str_mv | AT rammanoharbasnet zebrafishlarvaeasabehavioralmodelinneuropharmacology AT danielazizioli zebrafishlarvaeasabehavioralmodelinneuropharmacology AT somrattaweedet zebrafishlarvaeasabehavioralmodelinneuropharmacology AT dariofinazzi zebrafishlarvaeasabehavioralmodelinneuropharmacology AT mauriziomemo zebrafishlarvaeasabehavioralmodelinneuropharmacology |