Successful Treatment of Chronic Actinic Dermatitis with Dupilumab: A Case Report and Review of the Literature
Jiaoquan Chen, Huaping Li, Huilan Zhu Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, 510095, People’s Republic of ChinaCorrespondence: Huilan ZhuDepartment of Dermatology, Guangzhou Institute of Dermatology, 56 Hengfu Road, Guangzhou, 510095, People’s Republic of ChinaEmai...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-12-01
|
| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/successful-treatment-of-chronic-actinic-dermatitis-with-dupilumab-a-ca-peer-reviewed-fulltext-article-CCID |
| _version_ | 1818365727007047680 |
|---|---|
| author | Chen J Li H Zhu H |
| author_facet | Chen J Li H Zhu H |
| author_sort | Chen J |
| collection | DOAJ |
| description | Jiaoquan Chen, Huaping Li, Huilan Zhu Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, 510095, People’s Republic of ChinaCorrespondence: Huilan ZhuDepartment of Dermatology, Guangzhou Institute of Dermatology, 56 Hengfu Road, Guangzhou, 510095, People’s Republic of ChinaEmail Zhlhuilan@126.comAbstract: Chronic actinic dermatitis (CAD) is a rather rare photosensitive disease characterized by a persistent eczematous eruption in sun-exposed sites. The pathogenesis of CAD has not been completely elucidated. The clinical treatment of CAD is still challenging and not standardized. Some patients with severe CAD have achieved satisfactory clinical results with dupilumab when conventional therapies have failed. We herein report the case of a 45-year-old male with severe CAD who responded rapidly to combined treatment with dupilumab (600 mg for 1 week, and then 300 mg every 2 weeks) in 2 months. The patient experienced continuous improvement and no side effects from dupilumab (300 mg every month), having ceased other systemic medications. Dupilumab could be considered as an alternative or adjunctive treatment for CAD.Keywords: chronic actinic dermatitis, dupilumab, treatment |
| first_indexed | 2024-12-13T22:24:51Z |
| format | Article |
| id | doaj.art-bb311743eb5a4934812095005a042405 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-13T22:24:51Z |
| publishDate | 2021-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-bb311743eb5a4934812095005a0424052022-12-21T23:29:16ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152021-12-01Volume 141913191771892Successful Treatment of Chronic Actinic Dermatitis with Dupilumab: A Case Report and Review of the LiteratureChen JLi HZhu HJiaoquan Chen, Huaping Li, Huilan Zhu Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, 510095, People’s Republic of ChinaCorrespondence: Huilan ZhuDepartment of Dermatology, Guangzhou Institute of Dermatology, 56 Hengfu Road, Guangzhou, 510095, People’s Republic of ChinaEmail Zhlhuilan@126.comAbstract: Chronic actinic dermatitis (CAD) is a rather rare photosensitive disease characterized by a persistent eczematous eruption in sun-exposed sites. The pathogenesis of CAD has not been completely elucidated. The clinical treatment of CAD is still challenging and not standardized. Some patients with severe CAD have achieved satisfactory clinical results with dupilumab when conventional therapies have failed. We herein report the case of a 45-year-old male with severe CAD who responded rapidly to combined treatment with dupilumab (600 mg for 1 week, and then 300 mg every 2 weeks) in 2 months. The patient experienced continuous improvement and no side effects from dupilumab (300 mg every month), having ceased other systemic medications. Dupilumab could be considered as an alternative or adjunctive treatment for CAD.Keywords: chronic actinic dermatitis, dupilumab, treatmenthttps://www.dovepress.com/successful-treatment-of-chronic-actinic-dermatitis-with-dupilumab-a-ca-peer-reviewed-fulltext-article-CCIDchronic actinic dermatitisdupilumabtreatment |
| spellingShingle | Chen J Li H Zhu H Successful Treatment of Chronic Actinic Dermatitis with Dupilumab: A Case Report and Review of the Literature Clinical, Cosmetic and Investigational Dermatology chronic actinic dermatitis dupilumab treatment |
| title | Successful Treatment of Chronic Actinic Dermatitis with Dupilumab: A Case Report and Review of the Literature |
| title_full | Successful Treatment of Chronic Actinic Dermatitis with Dupilumab: A Case Report and Review of the Literature |
| title_fullStr | Successful Treatment of Chronic Actinic Dermatitis with Dupilumab: A Case Report and Review of the Literature |
| title_full_unstemmed | Successful Treatment of Chronic Actinic Dermatitis with Dupilumab: A Case Report and Review of the Literature |
| title_short | Successful Treatment of Chronic Actinic Dermatitis with Dupilumab: A Case Report and Review of the Literature |
| title_sort | successful treatment of chronic actinic dermatitis with dupilumab a case report and review of the literature |
| topic | chronic actinic dermatitis dupilumab treatment |
| url | https://www.dovepress.com/successful-treatment-of-chronic-actinic-dermatitis-with-dupilumab-a-ca-peer-reviewed-fulltext-article-CCID |
| work_keys_str_mv | AT chenj successfultreatmentofchronicactinicdermatitiswithdupilumabacasereportandreviewoftheliterature AT lih successfultreatmentofchronicactinicdermatitiswithdupilumabacasereportandreviewoftheliterature AT zhuh successfultreatmentofchronicactinicdermatitiswithdupilumabacasereportandreviewoftheliterature |