Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer

Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer

Estrogens have been shown to elicit anticancer effects against estrogen receptor α (ER)‐positive breast cancer. We sought to determine the mechanism underlying the therapeutic response. Response to 17β‐estradiol was assessed in ER+ breast cancer models with resistance to estrogen deprivation: WHIM16...

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Bibliographic Details
Main Authors: Sarah R. Hosford, Kevin Shee, Jason D. Wells, Nicole A. Traphagen, Jennifer L. Fields, Riley A. Hampsch, Arminja N. Kettenbach, Eugene Demidenko, Todd W. Miller
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Molecular Oncology
Subjects:
anti‐estrogen
breast cancer
endocrine
estrogen receptor
resistance
Online Access:https://doi.org/10.1002/1878-0261.12528

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