Treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel-coated versus conventional balloon angioplasty
Abstract Background Treatment of cephalic arch stenosis (CAS) with standard plain old balloon angioplasty (POBA) in dysfunctional arteriovenous fistulas (AVF), is associated with early re-stenosis and higher failure rates compared to other lesions. Paclitaxel-coated balloons (PCB) may improve patenc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-11-01
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| Series: | CVIR Endovascular |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42155-021-00271-1 |
| _version_ | 1818405352846131200 |
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| author | Ren Kwang A. Tng Ru Yu. Tan Shereen X. Y. Soon Suh Chien. Pang Chieh Suai. Tan Charyl J. Q. Yap Apoorva. Gogna Tze Tec. Chong Tjun Y. Tang |
| author_facet | Ren Kwang A. Tng Ru Yu. Tan Shereen X. Y. Soon Suh Chien. Pang Chieh Suai. Tan Charyl J. Q. Yap Apoorva. Gogna Tze Tec. Chong Tjun Y. Tang |
| author_sort | Ren Kwang A. Tng |
| collection | DOAJ |
| description | Abstract Background Treatment of cephalic arch stenosis (CAS) with standard plain old balloon angioplasty (POBA) in dysfunctional arteriovenous fistulas (AVF), is associated with early re-stenosis and higher failure rates compared to other lesions. Paclitaxel-coated balloons (PCB) may improve patency rates. This is a retrospective cohort study. Patients who underwent POBA or PCB for CAS over a 3-year period were included. Outcomes compared were circuit primary patency rates (patency from index procedure to next intervention), circuit primary assisted-patency rates (patency from index procedure to thrombosis), and target lesion (CAS) patency rates (stenosis > 50%) at 3, 6 and 12 months. Results Ninety-one patients were included. Sixty-five (71.4%) had POBA, while 26 (28.6%) had PCB angioplasty. There were 62 (68.1%) de-novo lesions. CAS was the only lesion that needed treatment in 24 (26.4%) patients. Circuit primary patency rates for POBA versus PCB groups were 76.2% vs. 60% (p = 0.21), 43.5% vs. 36% (p = 0.69) and 22% vs. 9.1% (p = 0.22) at 3, 6 and 12-months respectively. Circuit assisted-primary patency rates were 93.7% vs. 92% (p = 1.00), 87.1% vs. 80% (p = 0.51) and 76.3% vs. 81.8% (p = 0.77), whilst CAS target lesion intervention-free patency rates were 79.4% vs. 68% (p = 0.40), 51.6% vs. 52% (p = 1.00) and 33.9% vs. 22.7% (p = 0.49) at 3, 6 and 12-months respectively. Estimated mean time to target lesion intervention was 215 ± 183.2 days for POBA and 225 ± 186.6 days for PCB (p = 0.20). Conclusion Treatment of CAS with PCB did not improve target lesion or circuit patency rates compared to POBA. |
| first_indexed | 2024-12-14T08:54:41Z |
| format | Article |
| id | doaj.art-bb365d1fcc2841abbad974060110c30a |
| institution | Directory Open Access Journal |
| issn | 2520-8934 |
| language | English |
| last_indexed | 2024-12-14T08:54:41Z |
| publishDate | 2021-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | CVIR Endovascular |
| spelling | doaj.art-bb365d1fcc2841abbad974060110c30a2022-12-21T23:08:58ZengSpringerOpenCVIR Endovascular2520-89342021-11-01411710.1186/s42155-021-00271-1Treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel-coated versus conventional balloon angioplastyRen Kwang A. Tng0Ru Yu. Tan1Shereen X. Y. Soon2Suh Chien. Pang3Chieh Suai. Tan4Charyl J. Q. Yap5Apoorva. Gogna6Tze Tec. Chong7Tjun Y. Tang8Department of Renal Medicine, Singapore General HospitalDepartment of Renal Medicine, Singapore General HospitalDepartment of Vascular Surgery, Singapore General HospitalDepartment of Renal Medicine, Singapore General HospitalDepartment of Renal Medicine, Singapore General HospitalDepartment of Vascular Surgery, Singapore General HospitalDepartment of Vascular Interventional Radiology, Singapore General HospitalDepartment of Vascular Surgery, Singapore General HospitalDepartment of Vascular Surgery, Singapore General HospitalAbstract Background Treatment of cephalic arch stenosis (CAS) with standard plain old balloon angioplasty (POBA) in dysfunctional arteriovenous fistulas (AVF), is associated with early re-stenosis and higher failure rates compared to other lesions. Paclitaxel-coated balloons (PCB) may improve patency rates. This is a retrospective cohort study. Patients who underwent POBA or PCB for CAS over a 3-year period were included. Outcomes compared were circuit primary patency rates (patency from index procedure to next intervention), circuit primary assisted-patency rates (patency from index procedure to thrombosis), and target lesion (CAS) patency rates (stenosis > 50%) at 3, 6 and 12 months. Results Ninety-one patients were included. Sixty-five (71.4%) had POBA, while 26 (28.6%) had PCB angioplasty. There were 62 (68.1%) de-novo lesions. CAS was the only lesion that needed treatment in 24 (26.4%) patients. Circuit primary patency rates for POBA versus PCB groups were 76.2% vs. 60% (p = 0.21), 43.5% vs. 36% (p = 0.69) and 22% vs. 9.1% (p = 0.22) at 3, 6 and 12-months respectively. Circuit assisted-primary patency rates were 93.7% vs. 92% (p = 1.00), 87.1% vs. 80% (p = 0.51) and 76.3% vs. 81.8% (p = 0.77), whilst CAS target lesion intervention-free patency rates were 79.4% vs. 68% (p = 0.40), 51.6% vs. 52% (p = 1.00) and 33.9% vs. 22.7% (p = 0.49) at 3, 6 and 12-months respectively. Estimated mean time to target lesion intervention was 215 ± 183.2 days for POBA and 225 ± 186.6 days for PCB (p = 0.20). Conclusion Treatment of CAS with PCB did not improve target lesion or circuit patency rates compared to POBA.https://doi.org/10.1186/s42155-021-00271-1Cephalic arch stenosisPaclitaxelAngioplastyArteriovenous fistula |
| spellingShingle | Ren Kwang A. Tng Ru Yu. Tan Shereen X. Y. Soon Suh Chien. Pang Chieh Suai. Tan Charyl J. Q. Yap Apoorva. Gogna Tze Tec. Chong Tjun Y. Tang Treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel-coated versus conventional balloon angioplasty CVIR Endovascular Cephalic arch stenosis Paclitaxel Angioplasty Arteriovenous fistula |
| title | Treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel-coated versus conventional balloon angioplasty |
| title_full | Treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel-coated versus conventional balloon angioplasty |
| title_fullStr | Treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel-coated versus conventional balloon angioplasty |
| title_full_unstemmed | Treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel-coated versus conventional balloon angioplasty |
| title_short | Treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel-coated versus conventional balloon angioplasty |
| title_sort | treatment of cephalic arch stenosis in dysfunctional arteriovenous fistulas with paclitaxel coated versus conventional balloon angioplasty |
| topic | Cephalic arch stenosis Paclitaxel Angioplasty Arteriovenous fistula |
| url | https://doi.org/10.1186/s42155-021-00271-1 |
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