Is Cataract in Patients under 60 Years Associated with Oxidative Stress?
Oxidative stress is considered as a possible factor in the genesis of cataract. The study aimed to determine the systemic antioxidant status in cataract patients under 60 years. We studied 28 consecutive cataract patients, mean of 53 years (SD = 9.2), a range of 22–60 and 37 controls. In erythrocyte...
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MDPI AG
2023-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/5/1286 |
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| author | Hanna Lesiewska Alina Woźniak Paweł Reisner Krzysztof Czosnyka Joanna Stachura Grażyna Malukiewicz |
| author_facet | Hanna Lesiewska Alina Woźniak Paweł Reisner Krzysztof Czosnyka Joanna Stachura Grażyna Malukiewicz |
| author_sort | Hanna Lesiewska |
| collection | DOAJ |
| description | Oxidative stress is considered as a possible factor in the genesis of cataract. The study aimed to determine the systemic antioxidant status in cataract patients under 60 years. We studied 28 consecutive cataract patients, mean of 53 years (SD = 9.2), a range of 22–60 and 37 controls. In erythrocytes, activity of antioxidant enzymes was determined: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), in contrast with plasma concentrations of vitamin A and E. Conjugated dienes (CD) level and protein carbonyls (PC) concentration were also determined in plasma. Malondialdehyde (MDA) concentrations in erythrocytes and plasma were also measured. SOD and GPx activity and vitamin A and E concentrations were lower in cataract patients (<i>p</i> = 0.000511, 0.02, 0.022, and 0.000006, respectively). MDA plasma and erythrocytes concentrations were higher in cataract patients (<i>p</i> = 0.000001 and 0.0000001, respectively). PC concentration was higher in cataract patients than in controls (<i>p</i> = 0.00000013). There were statistically significant correlations between oxidative stress markers both in the cataract patients group as well as in the control group. Cataract incidence in patients under 60 years seems to be accompanied by enhanced lipid peroxidation and protein oxidation, as well as antioxidant defense depletion. Thus, supplementation with antioxidants could be beneficial in this group of patients. |
| first_indexed | 2024-03-11T03:56:04Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T03:56:04Z |
| publishDate | 2023-04-01 |
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| series | Biomedicines |
| spelling | doaj.art-bb3670962757471cbfa28506ffe3bb5b2023-11-18T00:34:45ZengMDPI AGBiomedicines2227-90592023-04-01115128610.3390/biomedicines11051286Is Cataract in Patients under 60 Years Associated with Oxidative Stress?Hanna Lesiewska0Alina Woźniak1Paweł Reisner2Krzysztof Czosnyka3Joanna Stachura4Grażyna Malukiewicz5Department of Ophthalmology, The Nicolaus Copernicus University, Ludwik Rydygier’s Collegium Medicum, 85-094 Bydgoszcz, PolandDepartment of Medical Biology and Biochemistry, The Nicolaus Copernicus University, Ludwik Rydygier’s Collegium Medicum, 85-094 Bydgoszcz, PolandDepartment of Ophthalmology, The Nicolaus Copernicus University, Ludwik Rydygier’s Collegium Medicum, 85-094 Bydgoszcz, PolandDepartment of Ophthalmology, The Nicolaus Copernicus University, Ludwik Rydygier’s Collegium Medicum, 85-094 Bydgoszcz, PolandDepartment of Ophthalmology, The Nicolaus Copernicus University, Ludwik Rydygier’s Collegium Medicum, 85-094 Bydgoszcz, PolandDepartment of Ophthalmology, The Nicolaus Copernicus University, Ludwik Rydygier’s Collegium Medicum, 85-094 Bydgoszcz, PolandOxidative stress is considered as a possible factor in the genesis of cataract. The study aimed to determine the systemic antioxidant status in cataract patients under 60 years. We studied 28 consecutive cataract patients, mean of 53 years (SD = 9.2), a range of 22–60 and 37 controls. In erythrocytes, activity of antioxidant enzymes was determined: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), in contrast with plasma concentrations of vitamin A and E. Conjugated dienes (CD) level and protein carbonyls (PC) concentration were also determined in plasma. Malondialdehyde (MDA) concentrations in erythrocytes and plasma were also measured. SOD and GPx activity and vitamin A and E concentrations were lower in cataract patients (<i>p</i> = 0.000511, 0.02, 0.022, and 0.000006, respectively). MDA plasma and erythrocytes concentrations were higher in cataract patients (<i>p</i> = 0.000001 and 0.0000001, respectively). PC concentration was higher in cataract patients than in controls (<i>p</i> = 0.00000013). There were statistically significant correlations between oxidative stress markers both in the cataract patients group as well as in the control group. Cataract incidence in patients under 60 years seems to be accompanied by enhanced lipid peroxidation and protein oxidation, as well as antioxidant defense depletion. Thus, supplementation with antioxidants could be beneficial in this group of patients.https://www.mdpi.com/2227-9059/11/5/1286presenile cataractoxidative stressantioxidant enzymeslipid peroxidation |
| spellingShingle | Hanna Lesiewska Alina Woźniak Paweł Reisner Krzysztof Czosnyka Joanna Stachura Grażyna Malukiewicz Is Cataract in Patients under 60 Years Associated with Oxidative Stress? Biomedicines presenile cataract oxidative stress antioxidant enzymes lipid peroxidation |
| title | Is Cataract in Patients under 60 Years Associated with Oxidative Stress? |
| title_full | Is Cataract in Patients under 60 Years Associated with Oxidative Stress? |
| title_fullStr | Is Cataract in Patients under 60 Years Associated with Oxidative Stress? |
| title_full_unstemmed | Is Cataract in Patients under 60 Years Associated with Oxidative Stress? |
| title_short | Is Cataract in Patients under 60 Years Associated with Oxidative Stress? |
| title_sort | is cataract in patients under 60 years associated with oxidative stress |
| topic | presenile cataract oxidative stress antioxidant enzymes lipid peroxidation |
| url | https://www.mdpi.com/2227-9059/11/5/1286 |
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