Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma
The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors. However, given the burden of mutations in the tumor microenvironment and lack of knowledge for the follow-up of advanced basal cell carcinoma, we...
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
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MDPI AG
2020-06-01
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| Σειρά: | Biomedicines |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.mdpi.com/2227-9059/8/6/156 |
| _version_ | 1827715222767403008 |
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| author | Terenzio Cosio Monia Di Prete Elena Campione |
| author_facet | Terenzio Cosio Monia Di Prete Elena Campione |
| author_sort | Terenzio Cosio |
| collection | DOAJ |
| description | The treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors. However, given the burden of mutations in the tumor microenvironment and lack of knowledge for the follow-up of advanced basal cell carcinoma, we are proposing a possible synergistic therapeutic application. Our aim is to underline the use of arsenic trioxide, itraconazole, all-trans-retinoic acid and nicotinamide as possible adjuvant therapies either in advanced not responding basal cell carcinoma or during follow-up based on Hedgehog pathway. We have analyzed the rational use of these drugs as a pivotal point to block neoplasm progression, modulate epigenetic modification and prevent recurrences. |
| first_indexed | 2024-03-10T19:14:22Z |
| format | Article |
| id | doaj.art-bb3a497d9cb447dc9e0439729392ea5f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T19:14:22Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-bb3a497d9cb447dc9e0439729392ea5f2023-11-20T03:30:53ZengMDPI AGBiomedicines2227-90592020-06-018615610.3390/biomedicines8060156Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell CarcinomaTerenzio Cosio0Monia Di Prete1Elena Campione2Department of Dermatology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyAnatomic Pathology Unit, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyDermatology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, ItalyThe treatment of advanced basal cell carcinoma has seen a progressive evolution in recent years following the introduction of Hedgehog pathway inhibitors. However, given the burden of mutations in the tumor microenvironment and lack of knowledge for the follow-up of advanced basal cell carcinoma, we are proposing a possible synergistic therapeutic application. Our aim is to underline the use of arsenic trioxide, itraconazole, all-trans-retinoic acid and nicotinamide as possible adjuvant therapies either in advanced not responding basal cell carcinoma or during follow-up based on Hedgehog pathway. We have analyzed the rational use of these drugs as a pivotal point to block neoplasm progression, modulate epigenetic modification and prevent recurrences.https://www.mdpi.com/2227-9059/8/6/156arsenic trioxidebasal cell carcinomaHedgehog signaling pathwayitraconazolenicotinamideretinoic acid |
| spellingShingle | Terenzio Cosio Monia Di Prete Elena Campione Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma Biomedicines arsenic trioxide basal cell carcinoma Hedgehog signaling pathway itraconazole nicotinamide retinoic acid |
| title | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma |
| title_full | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma |
| title_fullStr | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma |
| title_full_unstemmed | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma |
| title_short | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma |
| title_sort | arsenic trioxide itraconazole all trans retinoic acid and nicotinamide a proof of concept for combined treatments with hedgehog inhibitors in advanced basal cell carcinoma |
| topic | arsenic trioxide basal cell carcinoma Hedgehog signaling pathway itraconazole nicotinamide retinoic acid |
| url | https://www.mdpi.com/2227-9059/8/6/156 |
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