Role of brain-gut-muscle axis in human health and energy homeostasis
The interrelationship between brain, gut and skeletal muscle plays a key role in energy homeostasis of the body, and is becoming a hot topic of research. Intestinal microbial metabolites, such as short-chain fatty acids (SCFAs), bile acids (BAs) and tryptophan metabolites, communicate with the centr...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.947033/full |
| _version_ | 1798028225199210496 |
|---|---|
| author | Yunju Yin Yunju Yin Qiuping Guo Xihong Zhou Yehui Duan Yuhuan Yang Yuhuan Yang Saiming Gong Saiming Gong Mengmeng Han Mengmeng Han Yating Liu Zhikang Yang Qinghua Chen Fengna Li Fengna Li |
| author_facet | Yunju Yin Yunju Yin Qiuping Guo Xihong Zhou Yehui Duan Yuhuan Yang Yuhuan Yang Saiming Gong Saiming Gong Mengmeng Han Mengmeng Han Yating Liu Zhikang Yang Qinghua Chen Fengna Li Fengna Li |
| author_sort | Yunju Yin |
| collection | DOAJ |
| description | The interrelationship between brain, gut and skeletal muscle plays a key role in energy homeostasis of the body, and is becoming a hot topic of research. Intestinal microbial metabolites, such as short-chain fatty acids (SCFAs), bile acids (BAs) and tryptophan metabolites, communicate with the central nervous system (CNS) by binding to their receptors. In fact, there is a cross-talk between the CNS and the gut. The CNS, under the stimulation of pressure, will also affect the stability of the intestinal system, including the local intestinal transport, secretion and permeability of the intestinal system. After the gastrointestinal tract collects information about food absorption, it sends signals to the central system through vagus nerve and other channels to stimulate the secretion of brain-gut peptide and produce feeding behavior, which is also an important part of maintaining energy homeostasis. Skeletal muscle has receptors for SCFAs and BAs. Therefore, intestinal microbiota can participate in skeletal muscle energy metabolism and muscle fiber conversion through their metabolites. Skeletal muscles can also communicate with the gut system during exercise. Under the stimulation of exercise, myokines secreted by skeletal muscle causes the secretion of intestinal hormones, and these hormones can act on the central system and affect food intake. The idea of the brain-gut-muscle axis is gradually being confirmed, and at present it is important for regulating energy homeostasis, which also seems to be relevant to human health. This article focuses on the interaction of intestinal microbiota, central nervous, skeletal muscle energy metabolism, and feeding behavior regulation, which will provide new insight into the diagnostic and treatment strategies for obesity, diabetes, and other metabolic diseases. |
| first_indexed | 2024-04-11T19:04:27Z |
| format | Article |
| id | doaj.art-bb3af3da99284a80b8a1fe9924785b35 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-11T19:04:27Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-bb3af3da99284a80b8a1fe9924785b352022-12-22T04:07:50ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-10-01910.3389/fnut.2022.947033947033Role of brain-gut-muscle axis in human health and energy homeostasisYunju Yin0Yunju Yin1Qiuping Guo2Xihong Zhou3Yehui Duan4Yuhuan Yang5Yuhuan Yang6Saiming Gong7Saiming Gong8Mengmeng Han9Mengmeng Han10Yating Liu11Zhikang Yang12Qinghua Chen13Fengna Li14Fengna Li15College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, ChinaCollege of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, ChinaCollege of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, ChinaThe interrelationship between brain, gut and skeletal muscle plays a key role in energy homeostasis of the body, and is becoming a hot topic of research. Intestinal microbial metabolites, such as short-chain fatty acids (SCFAs), bile acids (BAs) and tryptophan metabolites, communicate with the central nervous system (CNS) by binding to their receptors. In fact, there is a cross-talk between the CNS and the gut. The CNS, under the stimulation of pressure, will also affect the stability of the intestinal system, including the local intestinal transport, secretion and permeability of the intestinal system. After the gastrointestinal tract collects information about food absorption, it sends signals to the central system through vagus nerve and other channels to stimulate the secretion of brain-gut peptide and produce feeding behavior, which is also an important part of maintaining energy homeostasis. Skeletal muscle has receptors for SCFAs and BAs. Therefore, intestinal microbiota can participate in skeletal muscle energy metabolism and muscle fiber conversion through their metabolites. Skeletal muscles can also communicate with the gut system during exercise. Under the stimulation of exercise, myokines secreted by skeletal muscle causes the secretion of intestinal hormones, and these hormones can act on the central system and affect food intake. The idea of the brain-gut-muscle axis is gradually being confirmed, and at present it is important for regulating energy homeostasis, which also seems to be relevant to human health. This article focuses on the interaction of intestinal microbiota, central nervous, skeletal muscle energy metabolism, and feeding behavior regulation, which will provide new insight into the diagnostic and treatment strategies for obesity, diabetes, and other metabolic diseases.https://www.frontiersin.org/articles/10.3389/fnut.2022.947033/fullenergyglucoseappetitemicrobiomemuscleCNS |
| spellingShingle | Yunju Yin Yunju Yin Qiuping Guo Xihong Zhou Yehui Duan Yuhuan Yang Yuhuan Yang Saiming Gong Saiming Gong Mengmeng Han Mengmeng Han Yating Liu Zhikang Yang Qinghua Chen Fengna Li Fengna Li Role of brain-gut-muscle axis in human health and energy homeostasis Frontiers in Nutrition energy glucose appetite microbiome muscle CNS |
| title | Role of brain-gut-muscle axis in human health and energy homeostasis |
| title_full | Role of brain-gut-muscle axis in human health and energy homeostasis |
| title_fullStr | Role of brain-gut-muscle axis in human health and energy homeostasis |
| title_full_unstemmed | Role of brain-gut-muscle axis in human health and energy homeostasis |
| title_short | Role of brain-gut-muscle axis in human health and energy homeostasis |
| title_sort | role of brain gut muscle axis in human health and energy homeostasis |
| topic | energy glucose appetite microbiome muscle CNS |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.947033/full |
| work_keys_str_mv | AT yunjuyin roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT yunjuyin roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT qiupingguo roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT xihongzhou roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT yehuiduan roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT yuhuanyang roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT yuhuanyang roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT saiminggong roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT saiminggong roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT mengmenghan roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT mengmenghan roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT yatingliu roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT zhikangyang roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT qinghuachen roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT fengnali roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis AT fengnali roleofbraingutmuscleaxisinhumanhealthandenergyhomeostasis |