Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere
Abstract Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve as natural hosts for several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Investigating the bat CoV community provides insights into the origin for highly pathogenic CoVs and highlights bat CoVs with p...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41264-z |
| _version_ | 1797558175516327936 |
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| author | Yelin Han Panpan Xu Yuyang Wang Wenliang Zhao Junpeng Zhang Shuyi Zhang Jianwei Wang Qi Jin Zhiqiang Wu |
| author_facet | Yelin Han Panpan Xu Yuyang Wang Wenliang Zhao Junpeng Zhang Shuyi Zhang Jianwei Wang Qi Jin Zhiqiang Wu |
| author_sort | Yelin Han |
| collection | DOAJ |
| description | Abstract Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve as natural hosts for several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Investigating the bat CoV community provides insights into the origin for highly pathogenic CoVs and highlights bat CoVs with potential spillover risks. This study probes the evolution, recombination, host range, geographical distribution, and cross-species transmission characteristics of bat CoVs across China and its associated CoVs in other regions. Through detailed research on 13,064 bat samples from 14 provinces of China, 1141 CoV strains are found across 10 subgenera and one unclassified Alpha-CoV, generating 399 complete genome sequences. Within bat CoVs, 11 new CoV species are identified and 425 recombination events are detected. Bats in southern China, particularly in Yunnan province, exhibit a pronounced diversity of CoVs. Limited sampling and low detection rates exist for CoVs in Myotacovirus, Nyctacovirus, Hibecovirus, Nobecovirus in China. The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV, indicating the complexity of cross-species transmission dynamics. Through the comprehensive analysis, this study enriches the understanding of bat CoVs and offers a valuable resource for future research. |
| first_indexed | 2024-03-10T17:26:44Z |
| format | Article |
| id | doaj.art-bb3eb35bf6c24d1386e4cd3976aeb088 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:26:44Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bb3eb35bf6c24d1386e4cd3976aeb0882023-11-20T10:09:37ZengNature PortfolioNature Communications2041-17232023-09-0114112010.1038/s41467-023-41264-zPanoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphereYelin Han0Panpan Xu1Yuyang Wang2Wenliang Zhao3Junpeng Zhang4Shuyi Zhang5Jianwei Wang6Qi Jin7Zhiqiang Wu8NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityCollege of Animal Science and Veterinary Medicine, Shenyang Agricultural UniversityNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeNHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeAbstract Bats, recognized as considerable reservoirs for coronaviruses (CoVs), serve as natural hosts for several highly pathogenic CoVs, including SARS-CoV and SARS-CoV-2. Investigating the bat CoV community provides insights into the origin for highly pathogenic CoVs and highlights bat CoVs with potential spillover risks. This study probes the evolution, recombination, host range, geographical distribution, and cross-species transmission characteristics of bat CoVs across China and its associated CoVs in other regions. Through detailed research on 13,064 bat samples from 14 provinces of China, 1141 CoV strains are found across 10 subgenera and one unclassified Alpha-CoV, generating 399 complete genome sequences. Within bat CoVs, 11 new CoV species are identified and 425 recombination events are detected. Bats in southern China, particularly in Yunnan province, exhibit a pronounced diversity of CoVs. Limited sampling and low detection rates exist for CoVs in Myotacovirus, Nyctacovirus, Hibecovirus, Nobecovirus in China. The genus Myotis is highlighted as a potential ancestral host for Alpha-CoV, with the genus Hipposideros suggested as a likely progenitor host for bat-associated Beta-CoV, indicating the complexity of cross-species transmission dynamics. Through the comprehensive analysis, this study enriches the understanding of bat CoVs and offers a valuable resource for future research.https://doi.org/10.1038/s41467-023-41264-z |
| spellingShingle | Yelin Han Panpan Xu Yuyang Wang Wenliang Zhao Junpeng Zhang Shuyi Zhang Jianwei Wang Qi Jin Zhiqiang Wu Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere Nature Communications |
| title | Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere |
| title_full | Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere |
| title_fullStr | Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere |
| title_full_unstemmed | Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere |
| title_short | Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere |
| title_sort | panoramic analysis of coronaviruses carried by representative bat species in southern china to better understand the coronavirus sphere |
| url | https://doi.org/10.1038/s41467-023-41264-z |
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