Therapeutic effect and mechanism of Anemarrhenae Rhizoma on Alzheimer’s disease based on multi-platform metabolomics analyses

Therapeutic effect and mechanism of Anemarrhenae Rhizoma on Alzheimer’s disease based on multi-platform metabolomics analyses

Anemarrhenae Rhizoma (AR) has multiple pharmacological activities to prevent and treat Alzheimer’s disease (AD). However, the effect and its molecular mechanism are not elucidated clear. This study aims to evaluate AR’s therapeutic effect and mechanism on AD model rats induced by D-galactose and AlC...

Full description

Bibliographic Details
Main Authors:	Hui Wang, Jian-Ying Dai, Yu-Zhen He, Zhe-Wei Xia, Xiao-Fei Chen, Zhan-Ying Hong, Yi-Feng Chai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Pharmacology
Subjects:	Alzheimer’s disease metabolomics Anemarrhenae Rhizoma LC-QTOF/MS GC-MS
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.940555/full

Similar Items

Analysis of Chemical Variations between Crude and Salt-Processed Anemarrhenae rhizoma Using Ultra-High-Performance Liquid Chromatography–Mass Spectrometry Methods
by: De Ji, et al.
Published: (2017-12-01)

Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC-Q-TOF/MS and HPLC-MS/MS
by: Wang Hai-Qiao, et al.
Published: (2021-12-01)

In Vitro Evaluation of the Interaction of Seven Biologically Active Components in <i>Anemarrhenae rhizoma</i> with P-gp
by: Jianying Dai, et al.
Published: (2022-12-01)

Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database
by: Lu Wang, et al.
Published: (2021-02-01)

Anti-Migraine Effect of the Herbal Combination of Chuanxiong Rhizoma and Cyperi Rhizoma and UPLC-MS/MS Method for the Simultaneous Quantification of the Active Constituents in Rat Serum and Cerebral Cortex
by: Sha Wu, et al.
Published: (2019-06-01)

Rapid Determination of 30 Polyphenols in Tongmai Formula, a Combination of Puerariae Lobatae Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Chuanxiong Rhizoma, via Liquid Chromatography-Tandem Mass Spectrometry
by: Fu-Rong Wang, et al.
Published: (2017-03-01)

Troubleshooting in Large-Scale LC-ToF-MS Metabolomics Analysis: Solving Complex Issues in Big Cohorts
by: Juan Rodríguez-Coira, et al.
Published: (2019-10-01)

Alkaloid profiling of the traditional Chinese medicine Rhizoma corydalis using high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry
by: Mingqian Sun, et al.
Published: (2014-06-01)

The complete chloroplast genome sequence of Anemarrhena asphodeloides Bunge
by: Fang Li, et al.
Published: (2019-01-01)

Metabolomic Analysis of Germinated Brown Rice at Different Germination Stages
by: Hoon Kim, et al.
Published: (2020-08-01)

Non-targeted plasma metabolome of early and late lactation gilts
by: Lea A Rempel, et al.
Published: (2016-11-01)

Metabolomics characterization of two saffron from Iran and China using GC–MS and LC–MS methods
by: Donglin Li, et al.
Published: (2024-02-01)

NMR Spectroscopy for Metabolomics Research
by: Abdul-Hamid Emwas, et al.
Published: (2019-06-01)

Antioxidants profile of Momordica charantia fruit extract analyzed using LC-MS-QTOF-based metabolomics
by: Vikneswari Perumal, et al.
Published: (2021-07-01)

Target and Suspect HRMS Metabolomics for the Determination of Functional Ingredients in 13 Varieties of Olive Leaves and Drupes from Greece
by: Evangelia Kritikou, et al.
Published: (2020-10-01)

Qualitative Factor-Based Comparison of NMR, Targeted and Untargeted GC-MS and LC-MS on the Metabolomic Profiles of Rioja and Priorat Red Wines
by: Dimitrios Kioroglou, et al.
Published: (2020-09-01)

The Application of Metabolomics in Recent Colorectal Cancer Studies: A State-of-the-Art Review
by: Andrew Gold, et al.
Published: (2022-01-01)

Comprehensive Metabolomic Comparison of Five Cereal Vinegars Using Non-Targeted and Chemical Isotope Labeling LC-MS Analysis
by: Zhihua Li, et al.
Published: (2022-05-01)

Anti-Inflammatory Activities of Compounds Isolated from the Rhizome of Anemarrhena asphodeloides
by: Zeyuan Wang, et al.
Published: (2018-10-01)

High-throughput screening of ancient forest plant extracts shows cytotoxicity towards triple-negative breast cancer
by: Yiyang Li, et al.
Published: (2023-11-01)

Analysis of Metabolic Components of JUNCAO Wine Based on GC-QTOF-MS
by: Jinlin Fan, et al.
Published: (2023-06-01)

Simultaneous Qualitative and Quantitative Evaluation of the Coptidis Rhizoma and Euodiae Fructus Herbal Pair by Using UHPLC-ESI-QTOF-MS and UHPLC-DAD
by: Yan-Ying Li, et al.
Published: (2020-10-01)

Metabolomics Research in Periodontal Disease by Mass Spectrometry
by: Sachio Tsuchida, et al.
Published: (2022-04-01)

Metabolic signatures and potential biomarkers of sarcopenia in suburb-dwelling older Chinese: based on untargeted GC–MS and LC–MS
by: Peipei Han, et al.
Published: (2024-03-01)

A Comprehensive Mass Spectrometry-Based Workflow for Clinical Metabolomics Cohort Studies
by: Zhan Shi, et al.
Published: (2022-11-01)

Linking metabolomics data to underlying metabolic regulation
by: Thomas eNägele
Published: (2014-11-01)

Untargeted metabolomics of pulmonary tuberculosis patient serum reveals potential prognostic markers of both latent infection and outcome
by: Xuezhi Wang, et al.
Published: (2022-11-01)

A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy
by: Baixin Kou, et al.
Published: (2023-10-01)

Study on the Mass Spectrometry Fragmentation Patterns for Rapid Screening and Structure Identification of Ketamine Analogues in Illicit Powders
by: Yilei Fan, et al.
Published: (2023-09-01)

Evaluation of the chronic intoxication of fluoride on human serum metabolome using untargeted metabolomics
by: Muhammad Usman, et al.
Published: (2022-07-01)

Comprehensive Metabolic Signature of Renal Dysplasia in Children. A Multiplatform Metabolomics Concept
by: Szymon Macioszek, et al.
Published: (2021-07-01)

Metabolomics Reveals Heterogeneity in the Chemical Composition of Green and White Spears of Asparagus (<i>A. officinalis</i>)
by: Eirini Pegiou, et al.
Published: (2021-10-01)

Metabolomic Analysis of Phytochemical Compounds from Ethanolic Extract of Lime (<i>Citrus aurantifolia</i>) Peel and Its Anti-Cancer Effects against Human Hepatocellular Carcinoma Cells
by: Pakkapong Phucharoenrak, et al.
Published: (2023-03-01)

Metabolomics and Network Pharmacology in the Exploration of the Multi-Targeted Therapeutic Approach of Traditional Medicinal Plants
by: Bharti Sharma, et al.
Published: (2022-11-01)

GC/MS and LC/MS Based Serum Metabolomic Analysis of Dairy Cows With Ovarian Inactivity
by: Yunlong Bai, et al.
Published: (2021-08-01)

<i>Anemarrhenae asphodeloides rhizoma</i> Extract Enriched in Mangiferin Protects PC12 Cells against a Neurotoxic Agent-3-Nitropropionic Acid
by: Agnieszka Piwowar, et al.
Published: (2020-04-01)

Integrated comparative metabolomics and network pharmacology approach to uncover the key active ingredients of Polygonati rhizoma and their therapeutic potential for the treatment of Alzheimer’s disease
by: Fu Wang, et al.
Published: (2022-08-01)

Integrated Lipidomics and Metabolomics Study of Four Chemically Induced Mouse Models of Acute Intrahepatic Cholestasis
by: Weiwei Li, et al.
Published: (2022-06-01)

A New Perspective on the Antimicrobial Mechanism of Berberine Hydrochloride Against Staphylococcus aureus Revealed by Untargeted Metabolomic Studies
by: Shu Wu, et al.
Published: (2022-07-01)

Metabolomics for Age Discrimination of Ginseng Using a Multiplex Approach to HR-MAS NMR Spectroscopy, UPLC–QTOF/MS, and GC × GC–TOF/MS
by: Dahye Yoon, et al.
Published: (2019-06-01)