Selective dry-cow therapy can be implemented successfully in cows of all milk production levels
ABSTRACT: Antibiotic stewardship on dairy farms can be heightened through the implementation of selective dry-cow therapy (SDCT). However, some producers are concerned that this practice may be related to poor udder health outcomes in cows with high milk production at the time of dry-off. The object...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Journal of Dairy Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022030223000139 |
| _version_ | 1797897321757802496 |
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| author | Sam Rowe Fidele Kabera Simon Dufour Sandra Godden Jean-Philippe Roy Daryl Nydam |
| author_facet | Sam Rowe Fidele Kabera Simon Dufour Sandra Godden Jean-Philippe Roy Daryl Nydam |
| author_sort | Sam Rowe |
| collection | DOAJ |
| description | ABSTRACT: Antibiotic stewardship on dairy farms can be heightened through the implementation of selective dry-cow therapy (SDCT). However, some producers are concerned that this practice may be related to poor udder health outcomes in cows with high milk production at the time of dry-off. The objective of this study was to evaluate if the effect of culture-guided SDCT (Cult-SDCT) and algorithm-guided SDCT (Alg-SDCT) on dry-period intramammary infection (IMI) dynamics and postcalving udder health and performance [when compared with blanket dry-cow therapy (BDCT)] varied according to milk production level before dry-off. Data were compiled from clinical trials conducted in the United States and Canada that compared Cult-SDCT and Alg-SDCT to a positive control, i.e., BDCT. In those trials, cows were enrolled 1–2 d before dry-off, randomized to their dry-cow therapy strategy and followed until 120 d in milk of the subsequent lactation. The number of cows and quarters in the final data set were 1,485 and 5,097, respectively. Measured outcomes included quarter-level antibiotic use at dry-off, quarter-level IMI prevalence after calving, quarter-level dry-period IMI cure risk, quarter-level dry-period new IMI risk, cow-level clinical mastitis and removal from the herd during 1–120 d in milk, and somatic cell count and milk yield during 1–120 DIM. The primary objective of analysis was to investigate if the effect of Cult-SDCT and Alg-SDCT on these outcomes, when compared with BDCT, varied according to milk production level before dry-off. To do this, each cow was classified as having low, mid or high production, based on her milk yield tertile group at the most recent herd test before enrollment (low: <23.7 kg/d, mid: 23.7 to 30.4 kg/d, and high >30.4 kg/d). Multivariable generalized estimating equations were used to estimate risk differences and differences in means, and Cox regression was used to estimate hazard ratios. For Cult-SDCT, the proportion of quarters treated with dry-cow antibiotics within each milk production level were 40.7% (low), 41.7% (mid) and 47.2% (high). For Alg-SDCT, the proportions were 60.6% (low), 38.7% (mid), and 35.1% (high). Measures of udder health were not markedly different when comparing Cult-SDCT to BDCT and Alg-SDCT to BDCT. This was consistently observed in low, mid and high producing cows. In conclusion, the findings from this study indicate that Cult-SDCT and Alg-SDCT can be successfully implemented in cows of all milk production levels. |
| first_indexed | 2024-04-10T07:56:43Z |
| format | Article |
| id | doaj.art-bb3f0cd5503542909ac560c31b1c9584 |
| institution | Directory Open Access Journal |
| issn | 0022-0302 |
| language | English |
| last_indexed | 2024-04-10T07:56:43Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
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| series | Journal of Dairy Science |
| spelling | doaj.art-bb3f0cd5503542909ac560c31b1c95842023-02-23T04:29:50ZengElsevierJournal of Dairy Science0022-03022023-03-01106319531967Selective dry-cow therapy can be implemented successfully in cows of all milk production levelsSam Rowe0Fidele Kabera1Simon Dufour2Sandra Godden3Jean-Philippe Roy4Daryl Nydam5Sydney School of Veterinary Science, The University of Sydney, Camden, New South Wales 2570, Australia; Department of Veterinary Population Medicine, University of Minnesota, St. Paul 55108; Corresponding authorDépartement de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada J2S 2M2; Mastitis Network, Saint-Hyacinthe, Quebec, Canada J2S 2M2Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada J2S 2M2; Mastitis Network, Saint-Hyacinthe, Quebec, Canada J2S 2M2Department of Veterinary Population Medicine, University of Minnesota, St. Paul 55108Mastitis Network, Saint-Hyacinthe, Quebec, Canada J2S 2M2; Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Quebec, Canada J2S 2M2Department of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853ABSTRACT: Antibiotic stewardship on dairy farms can be heightened through the implementation of selective dry-cow therapy (SDCT). However, some producers are concerned that this practice may be related to poor udder health outcomes in cows with high milk production at the time of dry-off. The objective of this study was to evaluate if the effect of culture-guided SDCT (Cult-SDCT) and algorithm-guided SDCT (Alg-SDCT) on dry-period intramammary infection (IMI) dynamics and postcalving udder health and performance [when compared with blanket dry-cow therapy (BDCT)] varied according to milk production level before dry-off. Data were compiled from clinical trials conducted in the United States and Canada that compared Cult-SDCT and Alg-SDCT to a positive control, i.e., BDCT. In those trials, cows were enrolled 1–2 d before dry-off, randomized to their dry-cow therapy strategy and followed until 120 d in milk of the subsequent lactation. The number of cows and quarters in the final data set were 1,485 and 5,097, respectively. Measured outcomes included quarter-level antibiotic use at dry-off, quarter-level IMI prevalence after calving, quarter-level dry-period IMI cure risk, quarter-level dry-period new IMI risk, cow-level clinical mastitis and removal from the herd during 1–120 d in milk, and somatic cell count and milk yield during 1–120 DIM. The primary objective of analysis was to investigate if the effect of Cult-SDCT and Alg-SDCT on these outcomes, when compared with BDCT, varied according to milk production level before dry-off. To do this, each cow was classified as having low, mid or high production, based on her milk yield tertile group at the most recent herd test before enrollment (low: <23.7 kg/d, mid: 23.7 to 30.4 kg/d, and high >30.4 kg/d). Multivariable generalized estimating equations were used to estimate risk differences and differences in means, and Cox regression was used to estimate hazard ratios. For Cult-SDCT, the proportion of quarters treated with dry-cow antibiotics within each milk production level were 40.7% (low), 41.7% (mid) and 47.2% (high). For Alg-SDCT, the proportions were 60.6% (low), 38.7% (mid), and 35.1% (high). Measures of udder health were not markedly different when comparing Cult-SDCT to BDCT and Alg-SDCT to BDCT. This was consistently observed in low, mid and high producing cows. In conclusion, the findings from this study indicate that Cult-SDCT and Alg-SDCT can be successfully implemented in cows of all milk production levels.http://www.sciencedirect.com/science/article/pii/S0022030223000139mastitisantimicrobial stewardshipdry-cow therapyantimicrobial resistance |
| spellingShingle | Sam Rowe Fidele Kabera Simon Dufour Sandra Godden Jean-Philippe Roy Daryl Nydam Selective dry-cow therapy can be implemented successfully in cows of all milk production levels Journal of Dairy Science mastitis antimicrobial stewardship dry-cow therapy antimicrobial resistance |
| title | Selective dry-cow therapy can be implemented successfully in cows of all milk production levels |
| title_full | Selective dry-cow therapy can be implemented successfully in cows of all milk production levels |
| title_fullStr | Selective dry-cow therapy can be implemented successfully in cows of all milk production levels |
| title_full_unstemmed | Selective dry-cow therapy can be implemented successfully in cows of all milk production levels |
| title_short | Selective dry-cow therapy can be implemented successfully in cows of all milk production levels |
| title_sort | selective dry cow therapy can be implemented successfully in cows of all milk production levels |
| topic | mastitis antimicrobial stewardship dry-cow therapy antimicrobial resistance |
| url | http://www.sciencedirect.com/science/article/pii/S0022030223000139 |
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