Dose Optimization of Aditoprim-Sulfamethoxazole Combinations Against Trueperella pyogenes From Patients With Clinical Endometritis by Using Semi-mechanistic PK/PD Model

Dose Optimization of Aditoprim-Sulfamethoxazole Combinations Against Trueperella pyogenes From Patients With Clinical Endometritis by Using Semi-mechanistic PK/PD Model

Combinations of two and more drugs with different target sites are being used as a new treatment regimen for resistant clones of bacteria. Though, achieving the right combination of the drugs for optimal dosage regimen is challenging. In our study, we studied the antimicrobial effect of aditoprim, a...

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Bibliographic Details
Main Authors: Muhammad Kashif Maan, Tamoor Hamid Chaudhry, Adeel Sattar, Muhammad Abu Bakr Shabbir, Saeed Ahmed, Kun Mi, Waqas Ahmed, Shuyu Xie, Li Xin, Lingli Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Pharmacology
Subjects:
PK/PD modeling
sulfamethoxazole resistance
aditorpim
combination therapy
Trueperella pyogenes
semi-mechanistic PK/PD modeling 3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.753359/full

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