Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells

Binding of copper is a mechanism of homocysteine toxicity leading to COX deficiency and apoptosis in primary neurons, PC12 and SHSY-5Y cells

Children with hereditary severe hyperhomocysteinemia present with a variety of neurological impairment, and mild hyperhomocysteinemia has been associated with neurodegeneration in the elderly. The link of hyperhomocysteinemia to neurological dysfunction is unknown. We investigated mitochondrial mech...

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Bibliographic Details
Main Authors: Michael Linnebank, Holger Lutz, Eva Jarre, Stefan Vielhaber, Carmen Noelker, Eduard Struys, Cornelis Jakobs, Thomas Klockgether, Bernd O. Evert, Wolfram S. Kunz, Ullrich Wüllner
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Subjects:
Copper
COX
Homocysteine
Homocystinuria
Hyperhomocysteinemia
Menkes disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001483

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