RNA Demethylase ALKBH5 Prevents Lung Cancer Progression by Regulating EMT and Stemness via Regulating p53

RNA Demethylase ALKBH5 Prevents Lung Cancer Progression by Regulating EMT and Stemness via Regulating p53

BackgroundAlthough N6-methyladenosine (m6A) RNA methylation is the most abundant reversible methylation of mRNA, which plays a critical role in regulating cancer processing, few studies have examined the role of m6A in nonsmall-cell lung cancer-derived cancer stem-like cells (CSCs).MethodsCSCs were...

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Bibliographic Details
Main Authors: Xiangli Liu, Ziyi Wang, Qiwei Yang, Xiaohai Hu, Qiang Fu, Xinyu Zhang, Wenya Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
nonsmall-cell lung cancer (NSCLC)
N6-methyladenosine (m6A) methylation
cancer stem-like cells (CSCs)
ALKBH5
epithelial and mesenchymal transition (EMT)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.858694/full

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