Anti-inflammatory activity of Ajmodadi Churna extract against acute inflammation in rats
Background : Ayurvedic polyherbal formulations are widely prescribed for a wide range of inflammatory conditions, yet, despite widespread use, there has been no systematic documentation of their safety and efficacy. Objective : The present study was undertaken to evaluate the anti-inflammatory activ...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-01-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
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| Online Access: | http://www.jaim.in/article.asp?issn=0975-9476;year=2012;volume=3;issue=1;spage=33;epage=37;aulast=Aswatha |
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| author | H N Aswatha Ram Neeraj K Sriwastava Inder K Makhija C S Shreedhara |
| author_facet | H N Aswatha Ram Neeraj K Sriwastava Inder K Makhija C S Shreedhara |
| author_sort | H N Aswatha Ram |
| collection | DOAJ |
| description | Background : Ayurvedic polyherbal formulations are widely prescribed for a wide range of inflammatory conditions, yet, despite widespread use, there has been no systematic documentation of their safety and efficacy. Objective : The present study was undertaken to evaluate the anti-inflammatory activity of aqueous extracts of Ajmodadi churna (AJM) in rats. Materials and Methods : Carrageenan-induced hind paw edema and air pouch inflammation models were used for the study. Results : The extracts showed significant antiinflammatory activity, reducing paw edema volume by 0.417 ± 0.097 and 0.379 ± 0.049, respectively. In the carrageenan-induced air pouch model, AJM reduced total leukocyte count by 73.09 ± 7.13 and 62.17 ± 10.53, granulocyte count by 69.48 ± 5.44 and 63.33 ± 4.13, and myeloperoxidase activity by 14.84 ± 0.91 and 18.44 ± 3.18, respectively, compared to controls. Discussion and Conclusion : AJM significantly reduced paw edema, during the second phase of edema development. In the carrageenan-induced air pouch model, AJM inhibited cellular infiltration into the air pouch fluid. We conclude that AJM is an effective candidate for prevention or treatment of acute inflammation |
| first_indexed | 2024-12-12T01:33:33Z |
| format | Article |
| id | doaj.art-bb433d7668064d23956ff7ed5258e77a |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-12-12T01:33:33Z |
| publishDate | 2012-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-bb433d7668064d23956ff7ed5258e77a2022-12-22T00:42:55ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762012-01-0131333710.4103/0975-9476.93946Anti-inflammatory activity of Ajmodadi Churna extract against acute inflammation in ratsH N Aswatha RamNeeraj K SriwastavaInder K MakhijaC S ShreedharaBackground : Ayurvedic polyherbal formulations are widely prescribed for a wide range of inflammatory conditions, yet, despite widespread use, there has been no systematic documentation of their safety and efficacy. Objective : The present study was undertaken to evaluate the anti-inflammatory activity of aqueous extracts of Ajmodadi churna (AJM) in rats. Materials and Methods : Carrageenan-induced hind paw edema and air pouch inflammation models were used for the study. Results : The extracts showed significant antiinflammatory activity, reducing paw edema volume by 0.417 ± 0.097 and 0.379 ± 0.049, respectively. In the carrageenan-induced air pouch model, AJM reduced total leukocyte count by 73.09 ± 7.13 and 62.17 ± 10.53, granulocyte count by 69.48 ± 5.44 and 63.33 ± 4.13, and myeloperoxidase activity by 14.84 ± 0.91 and 18.44 ± 3.18, respectively, compared to controls. Discussion and Conclusion : AJM significantly reduced paw edema, during the second phase of edema development. In the carrageenan-induced air pouch model, AJM inhibited cellular infiltration into the air pouch fluid. We conclude that AJM is an effective candidate for prevention or treatment of acute inflammationhttp://www.jaim.in/article.asp?issn=0975-9476;year=2012;volume=3;issue=1;spage=33;epage=37;aulast=AswathaAjmodadi churnagranulocyte countmyeloperoxidase activitypaw edematotal leukocyte count |
| spellingShingle | H N Aswatha Ram Neeraj K Sriwastava Inder K Makhija C S Shreedhara Anti-inflammatory activity of Ajmodadi Churna extract against acute inflammation in rats Journal of Ayurveda and Integrative Medicine Ajmodadi churna granulocyte count myeloperoxidase activity paw edema total leukocyte count |
| title | Anti-inflammatory activity of Ajmodadi Churna extract against acute inflammation in rats |
| title_full | Anti-inflammatory activity of Ajmodadi Churna extract against acute inflammation in rats |
| title_fullStr | Anti-inflammatory activity of Ajmodadi Churna extract against acute inflammation in rats |
| title_full_unstemmed | Anti-inflammatory activity of Ajmodadi Churna extract against acute inflammation in rats |
| title_short | Anti-inflammatory activity of Ajmodadi Churna extract against acute inflammation in rats |
| title_sort | anti inflammatory activity of ajmodadi churna extract against acute inflammation in rats |
| topic | Ajmodadi churna granulocyte count myeloperoxidase activity paw edema total leukocyte count |
| url | http://www.jaim.in/article.asp?issn=0975-9476;year=2012;volume=3;issue=1;spage=33;epage=37;aulast=Aswatha |
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