Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns
A systematic study of enantioresolution of a library of xanthonic derivatives, prepared “in-house”, was successfully carried out with four commercially available macrocyclic glycopeptide-based columns, namely ChirobioticTM T, ChirobioticTM R, ChirobioticTM V and ChirobioticTM TAG. Evaluation was con...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/1/142 |
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| author | Ye‛ Zaw Phyo Sara Cravo Andreia Palmeira Maria Elizabeth Tiritan Anake Kijjoa Madalena M. M. Pinto Carla Fernandes |
| author_facet | Ye‛ Zaw Phyo Sara Cravo Andreia Palmeira Maria Elizabeth Tiritan Anake Kijjoa Madalena M. M. Pinto Carla Fernandes |
| author_sort | Ye‛ Zaw Phyo |
| collection | DOAJ |
| description | A systematic study of enantioresolution of a library of xanthonic derivatives, prepared “in-house”, was successfully carried out with four commercially available macrocyclic glycopeptide-based columns, namely ChirobioticTM T, ChirobioticTM R, ChirobioticTM V and ChirobioticTM TAG. Evaluation was conducted in multimodal elution conditions: normal-phase, polar organic, polar ionic and reversed-phase. The effects of the mobile phase composition, the percentage of organic modifier, the pH of the mobile phase, the nature and concentration of different mobile phase additives on the chromatographic parameters are discussed. ChirobioticTM T and ChirobioticTM V, under normal-phase and reversed-phase modes, respectively, presented the best chromatographic parameters. Considering the importance of understanding the chiral recognition mechanisms associated with the chromatographic enantioresolution, and the scarce data available for macrocyclic glycopeptide-based columns, computational studies by molecular docking were also carried out. |
| first_indexed | 2024-04-13T22:16:43Z |
| format | Article |
| id | doaj.art-bb4654ce0f3d418a94b3a654f6d29714 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T22:16:43Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bb4654ce0f3d418a94b3a654f6d297142022-12-22T02:27:29ZengMDPI AGMolecules1420-30492018-01-0123114210.3390/molecules23010142molecules23010142Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic ColumnsYe‛ Zaw Phyo0Sara Cravo1Andreia Palmeira2Maria Elizabeth Tiritan3Anake Kijjoa4Madalena M. M. Pinto5Carla Fernandes6ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, PortugalInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, PortugalInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, PortugalInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, PortugalICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, PortugalInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, PortugalInterdisciplinary Centre of Marine and Environmental Research (CIIMAR), Edifício do Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4050-208 Matosinhos, PortugalA systematic study of enantioresolution of a library of xanthonic derivatives, prepared “in-house”, was successfully carried out with four commercially available macrocyclic glycopeptide-based columns, namely ChirobioticTM T, ChirobioticTM R, ChirobioticTM V and ChirobioticTM TAG. Evaluation was conducted in multimodal elution conditions: normal-phase, polar organic, polar ionic and reversed-phase. The effects of the mobile phase composition, the percentage of organic modifier, the pH of the mobile phase, the nature and concentration of different mobile phase additives on the chromatographic parameters are discussed. ChirobioticTM T and ChirobioticTM V, under normal-phase and reversed-phase modes, respectively, presented the best chromatographic parameters. Considering the importance of understanding the chiral recognition mechanisms associated with the chromatographic enantioresolution, and the scarce data available for macrocyclic glycopeptide-based columns, computational studies by molecular docking were also carried out.http://www.mdpi.com/1420-3049/23/1/142ChirobioticTMdockingenantioresolutionenantioselectivitymolecular recognitionxanthonic derivatives |
| spellingShingle | Ye‛ Zaw Phyo Sara Cravo Andreia Palmeira Maria Elizabeth Tiritan Anake Kijjoa Madalena M. M. Pinto Carla Fernandes Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns Molecules ChirobioticTM docking enantioresolution enantioselectivity molecular recognition xanthonic derivatives |
| title | Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns |
| title_full | Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns |
| title_fullStr | Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns |
| title_full_unstemmed | Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns |
| title_short | Enantiomeric Resolution and Docking Studies of Chiral Xanthonic Derivatives on Chirobiotic Columns |
| title_sort | enantiomeric resolution and docking studies of chiral xanthonic derivatives on chirobiotic columns |
| topic | ChirobioticTM docking enantioresolution enantioselectivity molecular recognition xanthonic derivatives |
| url | http://www.mdpi.com/1420-3049/23/1/142 |
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