Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing
Abstract Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use of antibiotics for infected wound management. Hence, a versatile hydrogel dressing (rGB/QCS/PDA–...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202206585 |
| _version_ | 1797846508188467200 |
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| author | Peng Zhao Yu Zhang Xiaoai Chen Chang Xu Jingzhe Guo Meigui Deng Xiongwei Qu Pingsheng Huang Zujian Feng Jimin Zhang |
| author_facet | Peng Zhao Yu Zhang Xiaoai Chen Chang Xu Jingzhe Guo Meigui Deng Xiongwei Qu Pingsheng Huang Zujian Feng Jimin Zhang |
| author_sort | Peng Zhao |
| collection | DOAJ |
| description | Abstract Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use of antibiotics for infected wound management. Hence, a versatile hydrogel dressing (rGB/QCS/PDA–PAM) exhibiting skin adaptiveness on dynamic wounds and mild photothermal antibacterial activity is developed for safe and efficient infected wound treatment. Phenylboronic acid‐functionalized graphene (rGB) and oxadiazole‐decorated quaternary carboxymethyl chitosan (QCS) are incorporated into a polydopamine–polyacrylamide (PDA–PAM) network with multiple covalent and noncovalent bonds, which conferred the hydrogel with flexible mechanical properties, strong tissue adhesion and excellent self‐healing ability on the dynamic wounds. Moreover, the glycocalyx‐mimicking phenylboronic acid on the surface of rGB enables the hydrogel to specifically capture bacteria. The enhanced membrane permeability of QCS enhanced bacterial vulnerability to photothermal therapy（PTT）, which is demonstrated by efficient mild PTT antibacteria against methicillin‐resistant Staphylococcus aureus in vitro and in vivo at temperatures of <49.6 °C. Consequently, the hydrogel demonstrate accelerated tissue regeneration on MRSA‐infected wound in vivo, with an intact epidermis, abundant collagen deposition and prominent angiogenesis. Therefore, rGB/QCS/PDA–PAM is a versatile hydrogel dressing exhibiting inherent antibacterial activity and has considerable potential in treating wounds infected with drug‐resistant bacteria. |
| first_indexed | 2024-04-09T17:57:10Z |
| format | Article |
| id | doaj.art-bb4701de61c74c3b90164bf95b551f59 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-09T17:57:10Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-bb4701de61c74c3b90164bf95b551f592023-04-14T19:54:19ZengWileyAdvanced Science2198-38442023-04-011011n/an/a10.1002/advs.202206585Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound HealingPeng Zhao0Yu Zhang1Xiaoai Chen2Chang Xu3Jingzhe Guo4Meigui Deng5Xiongwei Qu6Pingsheng Huang7Zujian Feng8Jimin Zhang9Hebei Key Laboratory of Functional Polymers School of Chemical Engineering and Technology Hebei University of Technology 5340 Xiping Road, Beichen District Tianjin 300130 P. R. ChinaHebei Key Laboratory of Functional Polymers School of Chemical Engineering and Technology Hebei University of Technology 5340 Xiping Road, Beichen District Tianjin 300130 P. R. ChinaHebei Key Laboratory of Functional Polymers School of Chemical Engineering and Technology Hebei University of Technology 5340 Xiping Road, Beichen District Tianjin 300130 P. R. ChinaHebei Key Laboratory of Functional Polymers School of Chemical Engineering and Technology Hebei University of Technology 5340 Xiping Road, Beichen District Tianjin 300130 P. R. ChinaHebei Key Laboratory of Functional Polymers School of Chemical Engineering and Technology Hebei University of Technology 5340 Xiping Road, Beichen District Tianjin 300130 P. R. ChinaHebei Key Laboratory of Functional Polymers School of Chemical Engineering and Technology Hebei University of Technology 5340 Xiping Road, Beichen District Tianjin 300130 P. R. ChinaHebei Key Laboratory of Functional Polymers School of Chemical Engineering and Technology Hebei University of Technology 5340 Xiping Road, Beichen District Tianjin 300130 P. R. ChinaTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College 236 Baidi Road, Nankai District Tianjin 300192 P. R. ChinaTianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College 236 Baidi Road, Nankai District Tianjin 300192 P. R. ChinaHebei Key Laboratory of Functional Polymers School of Chemical Engineering and Technology Hebei University of Technology 5340 Xiping Road, Beichen District Tianjin 300130 P. R. ChinaAbstract Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use of antibiotics for infected wound management. Hence, a versatile hydrogel dressing (rGB/QCS/PDA–PAM) exhibiting skin adaptiveness on dynamic wounds and mild photothermal antibacterial activity is developed for safe and efficient infected wound treatment. Phenylboronic acid‐functionalized graphene (rGB) and oxadiazole‐decorated quaternary carboxymethyl chitosan (QCS) are incorporated into a polydopamine–polyacrylamide (PDA–PAM) network with multiple covalent and noncovalent bonds, which conferred the hydrogel with flexible mechanical properties, strong tissue adhesion and excellent self‐healing ability on the dynamic wounds. Moreover, the glycocalyx‐mimicking phenylboronic acid on the surface of rGB enables the hydrogel to specifically capture bacteria. The enhanced membrane permeability of QCS enhanced bacterial vulnerability to photothermal therapy（PTT）, which is demonstrated by efficient mild PTT antibacteria against methicillin‐resistant Staphylococcus aureus in vitro and in vivo at temperatures of <49.6 °C. Consequently, the hydrogel demonstrate accelerated tissue regeneration on MRSA‐infected wound in vivo, with an intact epidermis, abundant collagen deposition and prominent angiogenesis. Therefore, rGB/QCS/PDA–PAM is a versatile hydrogel dressing exhibiting inherent antibacterial activity and has considerable potential in treating wounds infected with drug‐resistant bacteria.https://doi.org/10.1002/advs.202206585hydrogel dressingmild photothermal antibacterialMRSA infected wound healingskin‐adaptiveness |
| spellingShingle | Peng Zhao Yu Zhang Xiaoai Chen Chang Xu Jingzhe Guo Meigui Deng Xiongwei Qu Pingsheng Huang Zujian Feng Jimin Zhang Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing Advanced Science hydrogel dressing mild photothermal antibacterial MRSA infected wound healing skin‐adaptiveness |
| title | Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing |
| title_full | Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing |
| title_fullStr | Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing |
| title_full_unstemmed | Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing |
| title_short | Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing |
| title_sort | versatile hydrogel dressing with skin adaptiveness and mild photothermal antibacterial activity for methicillin resistant staphylococcus aureus infected dynamic wound healing |
| topic | hydrogel dressing mild photothermal antibacterial MRSA infected wound healing skin‐adaptiveness |
| url | https://doi.org/10.1002/advs.202206585 |
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