Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status
Abstract Background Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3869-1 |
| _version_ | 1818534754798010368 |
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| author | Li-Ni Liu Yung-Chang Lin Christine Miaskowski Shin-Cheh Chen Mei-Ling Chen |
| author_facet | Li-Ni Liu Yung-Chang Lin Christine Miaskowski Shin-Cheh Chen Mei-Ling Chen |
| author_sort | Li-Ni Liu |
| collection | DOAJ |
| description | Abstract Background Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after breast cancer surgery and how this relationship is influenced by menopausal status. Methods Body fat percentage was measured 1 day before and 6 months after surgery in 131 women with stages 0–III breast cancer. Disease outcomes (metastasis and death) were assessed by chart review and telephone contact 7 to 8 years after diagnosis. These data were analyzed by multivariate Cox proportional hazard model analysis. Results The percentage of women with over 5% gain in body-fat was 56% for premenopausal and 42% for postmenopausal. Rates of distant metastasis and all-cause mortality were 17.6 and 9.9%, respectively over the follow-up period. Distant metastases were predicted in postmenopausal but not premenopausal women with breast cancer by increased body fat percentage (HR = 1.3, p = 0.035), after controlling other potential covariates, including disease severity, estrogen receptor expression, progesterone receptors expression, age, and exercise habit before diagnosis. Survival was not significantly associated with body-fat percentage gains. Conclusions Our results suggest that increased body fat percentage 6 months after breast surgery is an important predictor of distant metastasis in postmenopausal Taiwanese women with breast cancer. Clinicians may need to measure patients’ body fat periodically. Our findings should be validated in studies with a longer follow-up time. |
| first_indexed | 2024-12-11T18:15:41Z |
| format | Article |
| id | doaj.art-bb47ae7ccb8041d387374e56f357dd8b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T18:15:41Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-bb47ae7ccb8041d387374e56f357dd8b2022-12-22T00:55:27ZengBMCBMC Cancer1471-24072017-12-011711710.1186/s12885-017-3869-1Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal statusLi-Ni Liu0Yung-Chang Lin1Christine Miaskowski2Shin-Cheh Chen3Mei-Ling Chen4Department of Nursing, Fu Jen Catholic UniversityDepartment of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung UniversityDepartment of Physiological Nursing, School of Nursing, University of CaliforniaDepartment of Surgery, Chang Gung Memorial Hospital and Chang Gung UniversityDepartment of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung UniversityAbstract Background Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after breast cancer surgery and how this relationship is influenced by menopausal status. Methods Body fat percentage was measured 1 day before and 6 months after surgery in 131 women with stages 0–III breast cancer. Disease outcomes (metastasis and death) were assessed by chart review and telephone contact 7 to 8 years after diagnosis. These data were analyzed by multivariate Cox proportional hazard model analysis. Results The percentage of women with over 5% gain in body-fat was 56% for premenopausal and 42% for postmenopausal. Rates of distant metastasis and all-cause mortality were 17.6 and 9.9%, respectively over the follow-up period. Distant metastases were predicted in postmenopausal but not premenopausal women with breast cancer by increased body fat percentage (HR = 1.3, p = 0.035), after controlling other potential covariates, including disease severity, estrogen receptor expression, progesterone receptors expression, age, and exercise habit before diagnosis. Survival was not significantly associated with body-fat percentage gains. Conclusions Our results suggest that increased body fat percentage 6 months after breast surgery is an important predictor of distant metastasis in postmenopausal Taiwanese women with breast cancer. Clinicians may need to measure patients’ body fat periodically. Our findings should be validated in studies with a longer follow-up time.http://link.springer.com/article/10.1186/s12885-017-3869-1Breast cancerMenopausal statusBody fatDisease progression |
| spellingShingle | Li-Ni Liu Yung-Chang Lin Christine Miaskowski Shin-Cheh Chen Mei-Ling Chen Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status BMC Cancer Breast cancer Menopausal status Body fat Disease progression |
| title | Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status |
| title_full | Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status |
| title_fullStr | Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status |
| title_full_unstemmed | Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status |
| title_short | Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status |
| title_sort | association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status |
| topic | Breast cancer Menopausal status Body fat Disease progression |
| url | http://link.springer.com/article/10.1186/s12885-017-3869-1 |
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