Characterization and Biological Evaluation of Propolis from Poland
In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC–MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of Populus nigra (section Aigeiros) were determined, however, glycerol esters of phenolic...
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MDPI AG
2017-07-01
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| author | Milena Popova Efstathia Giannopoulou Krystyna Skalicka-Woźniak Konstantia Graikou Jaroslaw Widelski Vassya Bankova Haralabos Kalofonos Gregory Sivolapenko Katarzyna Gaweł-Bęben Beata Antosiewicz Ioanna Chinou |
| author_facet | Milena Popova Efstathia Giannopoulou Krystyna Skalicka-Woźniak Konstantia Graikou Jaroslaw Widelski Vassya Bankova Haralabos Kalofonos Gregory Sivolapenko Katarzyna Gaweł-Bęben Beata Antosiewicz Ioanna Chinou |
| author_sort | Milena Popova |
| collection | DOAJ |
| description | In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC–MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of Populus nigra (section Aigeiros) were determined, however, glycerol esters of phenolic acids, as well as unusually high amounts of p-coumaric and ferulic acid and their benzyl esters, were also detected. These constituents are characteristic for buds of Populus tremula (section Leuce). We also evaluated the antiproliferative effect of propolis extracts against nine human cancer cell lines. Additionally, promising antibacterial activity of the dichloromethane extract (Minimal Inhibitory Concentration MIC values of 0.95–1.24 mg/mL), as well as a moderate antifungal activity (MIC values of 1.25–1.40 mg/mL), was noticed. Propolis from Poland appeared as a rich source of antibacterial and antiproliferative compounds and this confirmed that it is a valuable natural product with the potential to improve human health. |
| first_indexed | 2024-12-11T07:37:36Z |
| format | Article |
| id | doaj.art-bb4c703075c44f9e94935fad21a8c3f6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T07:37:36Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-bb4c703075c44f9e94935fad21a8c3f62022-12-22T01:15:40ZengMDPI AGMolecules1420-30492017-07-01227115910.3390/molecules22071159molecules22071159Characterization and Biological Evaluation of Propolis from PolandMilena Popova0Efstathia Giannopoulou1Krystyna Skalicka-Woźniak2Konstantia Graikou3Jaroslaw Widelski4Vassya Bankova5Haralabos Kalofonos6Gregory Sivolapenko7Katarzyna Gaweł-Bęben8Beata Antosiewicz9Ioanna Chinou10Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaClinical Oncology Laboratory, University Hospital of Patras, Patras Medical School, 26504 Rio, GreeceDepartment of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 20093 Lublin, PolandDivision of Pharmacognosy and Chemistry of Natural Products, Departments of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, GreeceDepartment of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 20093 Lublin, PolandInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, BulgariaClinical Oncology Laboratory, University Hospital of Patras, Patras Medical School, 26504 Rio, GreecePharmacokinetics Laboratory, Department of Pharmacy, University of Patras, 26504 Rio, GreeceDepartment of Cosmetology, University of Information Technology and Management in Rzeszow, 35225 Rzeszów, PolandDepartment of Cosmetology, University of Information Technology and Management in Rzeszow, 35225 Rzeszów, PolandDivision of Pharmacognosy and Chemistry of Natural Products, Departments of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, GreeceIn this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC–MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of Populus nigra (section Aigeiros) were determined, however, glycerol esters of phenolic acids, as well as unusually high amounts of p-coumaric and ferulic acid and their benzyl esters, were also detected. These constituents are characteristic for buds of Populus tremula (section Leuce). We also evaluated the antiproliferative effect of propolis extracts against nine human cancer cell lines. Additionally, promising antibacterial activity of the dichloromethane extract (Minimal Inhibitory Concentration MIC values of 0.95–1.24 mg/mL), as well as a moderate antifungal activity (MIC values of 1.25–1.40 mg/mL), was noticed. Propolis from Poland appeared as a rich source of antibacterial and antiproliferative compounds and this confirmed that it is a valuable natural product with the potential to improve human health.https://www.mdpi.com/1420-3049/22/7/1159GC–MScytotoxic activityPolish propolisPopulus nigraPopulus tremula |
| spellingShingle | Milena Popova Efstathia Giannopoulou Krystyna Skalicka-Woźniak Konstantia Graikou Jaroslaw Widelski Vassya Bankova Haralabos Kalofonos Gregory Sivolapenko Katarzyna Gaweł-Bęben Beata Antosiewicz Ioanna Chinou Characterization and Biological Evaluation of Propolis from Poland Molecules GC–MS cytotoxic activity Polish propolis Populus nigra Populus tremula |
| title | Characterization and Biological Evaluation of Propolis from Poland |
| title_full | Characterization and Biological Evaluation of Propolis from Poland |
| title_fullStr | Characterization and Biological Evaluation of Propolis from Poland |
| title_full_unstemmed | Characterization and Biological Evaluation of Propolis from Poland |
| title_short | Characterization and Biological Evaluation of Propolis from Poland |
| title_sort | characterization and biological evaluation of propolis from poland |
| topic | GC–MS cytotoxic activity Polish propolis Populus nigra Populus tremula |
| url | https://www.mdpi.com/1420-3049/22/7/1159 |
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