The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer

The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer

Cell-mediated immunity is driven by antigenic peptide presentation on major histocompatibility complex (MHC) molecules. Specialized proteasome complexes called immunoproteasomes process viral, bacterial, and tumor antigens for presentation on MHC class I molecules, which can induce CD8 T cells to mo...

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Bibliographic Details
Main Authors: Satyendra Chandra Tripathi, Disha Vedpathak, Edwin Justin Ostrin
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
ubiquitin–proteasome system (UPS)
immunoproteasome
solid tumors
proteasome inhibitors
Online Access:https://www.mdpi.com/2073-4409/10/12/3587

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