Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort
Abstract Objective Investigate the longitudinal association of use and time of use of proton pump inhibitors (PPI) with incidence of chronic kidney disease (CKD) and kidney function change. Methods Prospective study with 13,909 participants from baseline (2008–2010) and second wave (2012–2014) of th...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-023-03300-4 |
| _version_ | 1797577531274035200 |
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| author | Andrêza Soares dos Santos Sara Teles de Menezes Isabella Ribeiro Silva William Neves Oliveira Mariana Linhares Pereira José Geraldo Mill Sandhi Maria Barreto Roberta Carvalho Figueiredo |
| author_facet | Andrêza Soares dos Santos Sara Teles de Menezes Isabella Ribeiro Silva William Neves Oliveira Mariana Linhares Pereira José Geraldo Mill Sandhi Maria Barreto Roberta Carvalho Figueiredo |
| author_sort | Andrêza Soares dos Santos |
| collection | DOAJ |
| description | Abstract Objective Investigate the longitudinal association of use and time of use of proton pump inhibitors (PPI) with incidence of chronic kidney disease (CKD) and kidney function change. Methods Prospective study with 13,909 participants from baseline (2008–2010) and second wave (2012–2014) of the ELSA-Brasil (mean interval between visits = 3.9 years (1.7–6.0)). Participants answered about use and time use of the PPI in the two weeks prior the interview. Renal function was assessed by glomerular filtration rate estimated by the Collaboration Equation for the Epidemiology of Chronic Kidney Disease. Values below 60ml/min/1.73 m² in wave 2 were considered incident CKD. Associations between PPI use and time of use at baseline and incident CKD and decline in renal function were estimated, respectively, by logistic regression and linear models with mixed effects, after adjusting for confounders. Results After adjustments, PPI users for more than six months had an increased risk of CKD compared to non-users. Compared to non-users, users PPIs for up to six months and above six months had greater decline in kidney function over time. Conclusion This cohort of adults and elderly, after a mean interval of 3.9 years, PPI use and initial duration were associated with kidney function change between visits. |
| first_indexed | 2024-03-10T22:09:40Z |
| format | Article |
| id | doaj.art-bb4d2ef872244f7cb7086d099c807965 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-03-10T22:09:40Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-bb4d2ef872244f7cb7086d099c8079652023-11-19T12:39:18ZengBMCBMC Nephrology1471-23692023-09-0124111010.1186/s12882-023-03300-4Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohortAndrêza Soares dos Santos0Sara Teles de Menezes1Isabella Ribeiro Silva2William Neves Oliveira3Mariana Linhares Pereira4José Geraldo Mill5Sandhi Maria Barreto6Roberta Carvalho Figueiredo7Postgraduate Program in Health Sciences, Universidade Federal de São João del-ReiLongitudinal Study of Adult Health – ELSA-Brasil, Medical School & Clinical Hospital/EBSERH, Universidade Federal de Minas GeraisPostgraduate Program in Health Sciences, Universidade Federal de São João del-ReiPostgraduate Program in Health Sciences, Universidade Federal de São João del-ReiPostgraduate Program in Health Sciences, Universidade Federal de São João del-ReiDepartment of Physiological Sciences & University Hospital, Universidade Federal do Espírito SantoMedical School & Clinical Hospital/EBSERH, Universidade Federal de Minas GeraisPostgraduate Program in Health Sciences, Universidade Federal de São João del-ReiAbstract Objective Investigate the longitudinal association of use and time of use of proton pump inhibitors (PPI) with incidence of chronic kidney disease (CKD) and kidney function change. Methods Prospective study with 13,909 participants from baseline (2008–2010) and second wave (2012–2014) of the ELSA-Brasil (mean interval between visits = 3.9 years (1.7–6.0)). Participants answered about use and time use of the PPI in the two weeks prior the interview. Renal function was assessed by glomerular filtration rate estimated by the Collaboration Equation for the Epidemiology of Chronic Kidney Disease. Values below 60ml/min/1.73 m² in wave 2 were considered incident CKD. Associations between PPI use and time of use at baseline and incident CKD and decline in renal function were estimated, respectively, by logistic regression and linear models with mixed effects, after adjusting for confounders. Results After adjustments, PPI users for more than six months had an increased risk of CKD compared to non-users. Compared to non-users, users PPIs for up to six months and above six months had greater decline in kidney function over time. Conclusion This cohort of adults and elderly, after a mean interval of 3.9 years, PPI use and initial duration were associated with kidney function change between visits.https://doi.org/10.1186/s12882-023-03300-4Proton pump inhibitorsChronic kidney diseaseKidney functionPharmacovigilancePharmacoepidemiology |
| spellingShingle | Andrêza Soares dos Santos Sara Teles de Menezes Isabella Ribeiro Silva William Neves Oliveira Mariana Linhares Pereira José Geraldo Mill Sandhi Maria Barreto Roberta Carvalho Figueiredo Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort BMC Nephrology Proton pump inhibitors Chronic kidney disease Kidney function Pharmacovigilance Pharmacoepidemiology |
| title | Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort |
| title_full | Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort |
| title_fullStr | Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort |
| title_full_unstemmed | Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort |
| title_short | Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort |
| title_sort | kidney function decline associated with proton pump inhibitors results from the elsa brasil cohort |
| topic | Proton pump inhibitors Chronic kidney disease Kidney function Pharmacovigilance Pharmacoepidemiology |
| url | https://doi.org/10.1186/s12882-023-03300-4 |
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