Promotion of cytoplasmic vacuolation-mediated cell death of human prostate cancer PC-3 cells by oxidative stress induced by daucusol, a new guaiane-type sesquiterpenoid from Daucus carota L.

Promotion of cytoplasmic vacuolation-mediated cell death of human prostate cancer PC-3 cells by oxidative stress induced by daucusol, a new guaiane-type sesquiterpenoid from Daucus carota L.

We investigated the antitumor activity of daucusol (DS) derived from Daucus carota L. in PC-3, A549 and HeLa cell lines by the MTT assay. Optical microscopy revealed that exposure of PC-3 cells to DS resulted in cytoplasmic vacuolation. Flow cytometry analysis of the phase of the cell cycle did not...

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Bibliographic Details
Main Authors: Han Haote, Liu Na, Zhang Lin, Gong Minghua, Cao Ming, Li Baoguo, Kaisa Sulaiman, Yu Xiuying, Tian Jingkui
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2017-01-01
Series:Archives of Biological Sciences
Subjects:
daucusol
cytoplasmic vacuolation
oxidative stress
endoplasmic reticulum stress
prostate cancer
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2017/0354-46641600123H.pdf

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