Bioinspired Pyrano[2,3-<i>f</i>]chromen-8-ones: Ring C-Opened Analogues of Calanolide A: Synthesis and Anti-HIV-1 Evaluation

Bioinspired Pyrano[2,3-<i>f</i>]chromen-8-ones: Ring C-Opened Analogues of Calanolide A: Synthesis and Anti-HIV-1 Evaluation

We have designed and synthesized a series of bioinspired pyrano[2,3-<i>f</i>]coumarin-based Calanolide A analogs with anti-HIV activity. The design of these new calanolide analogs involved incorporating nitrogen heterocycles or aromatic groups in lieu of ring C, effectively mimicking and...

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Bibliographic Details
Main Authors: Igor A. Khalymbadzha, Ramil F. Fatykhov, Ilya I. Butorin, Ainur D. Sharapov, Anastasia P. Potapova, Nibin Joy Muthipeedika, Grigory V. Zyryanov, Vsevolod V. Melekhin, Maria D. Tokhtueva, Sergey L. Deev, Marina K. Kukhanova, Nataliya N. Mochulskaya, Mikhail V. Tsurkan
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomimetics
Subjects:
Calanolide A
anti-HIV activity
reverse transcriptase
non-nucleoside reverse transcriptase inhibitors (NNRTIs)
Mannich reaction
CH/CH-coupling
Online Access:https://www.mdpi.com/2313-7673/9/1/44

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