Zinc Exposure Promotes Commensal-to-Pathogen Transition in <i>Pseudomonas aeruginosa</i> Leading to Mucosal Inflammation and Illness in Mice

Zinc Exposure Promotes Commensal-to-Pathogen Transition in <i>Pseudomonas aeruginosa</i> Leading to Mucosal Inflammation and Illness in Mice

The opportunistic pathogen <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>) is associated gastrointestinal (GI) inflammation and illness; however, factors motivating commensal-to-pathogen transition are unclear. Excessive zinc intake from supplements is common in humans....

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Bibliographic Details
Main Authors: Tong Wu, Annie Gagnon, Katherine McGourty, Rebecca DosSantos, Lucia Chanetsa, Boce Zhang, Dhimiter Bello, Shannon L. Kelleher
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
zinc
<i>Pseudomonas aeruginosa</i>
virulence
Caco-2 cells
intestinal permeability
colonic inflammation
Online Access:https://www.mdpi.com/1422-0067/22/24/13321

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