Single-Dose Intranasal Treatment with DEF201 (Adenovirus Vectored Consensus Interferon) Prevents Lethal Disease Due to Rift Valley Fever Virus Challenge

Single-Dose Intranasal Treatment with DEF201 (Adenovirus Vectored Consensus Interferon) Prevents Lethal Disease Due to Rift Valley Fever Virus Challenge

Rift Valley fever virus (RVFV) causes severe disease in humans and ungulates. The virus can be transmitted by mosquitoes, direct contact with infected tissues or fluids, or aerosol, making it a significant biological threat for which there is no approved vaccine or therapeutic. Herein we describe th...

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Bibliographic Details
Main Authors: Brian B. Gowen, Jane Ennis, Kevin W. Bailey, Zachary Vest, Dionna Scharton, Eric J. Sefing, Jeffrey D. Turner
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Viruses
Subjects:
Rift Valley Fever Virus (RVFV)
phlebovirus
bunyavirus
interferon alpha
DEF201
antiviral
Online Access:http://www.mdpi.com/1999-4915/6/3/1410

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