MicroRNA in Lung Cancer Metastasis
Tumor metastasis is a hallmark of cancer, with distant metastasis frequently developing in lung cancer, even at initial diagnosis, resulting in poor prognosis and high mortality. However, available biomarkers cannot reliably predict cancer spreading sites. The metastatic cascade involves highly comp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/2/265 |
| _version_ | 1797713031933722624 |
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| author | Shang-Gin Wu Tzu-Hua Chang Yi-Nan Liu Jin-Yuan Shih |
| author_facet | Shang-Gin Wu Tzu-Hua Chang Yi-Nan Liu Jin-Yuan Shih |
| author_sort | Shang-Gin Wu |
| collection | DOAJ |
| description | Tumor metastasis is a hallmark of cancer, with distant metastasis frequently developing in lung cancer, even at initial diagnosis, resulting in poor prognosis and high mortality. However, available biomarkers cannot reliably predict cancer spreading sites. The metastatic cascade involves highly complicated processes including invasion, migration, angiogenesis, and epithelial-to-mesenchymal transition that are tightly controlled by various genetic expression modalities along with interaction between cancer cells and the extracellular matrix. In particular, microRNAs (miRNAs), a group of small non-coding RNAs, can influence the transcriptional and post-transcriptional processes, with dysregulation of miRNA expression contributing to the regulation of cancer metastasis. Nevertheless, although miRNA-targeted therapy is widely studied in vitro and in vivo, this strategy currently affords limited feasibility and a few miRNA-targeted therapies for lung cancer have entered into clinical trials to date. Advances in understanding the molecular mechanism of metastasis will thus provide additional potential targets for lung cancer treatment. This review discusses the current research related to the role of miRNAs in lung cancer invasion and metastasis, with a particular focus on the different metastatic lesions and potential miRNA-targeted treatments for lung cancer with the expectation that further exploration of miRNA-targeted therapy may establish a new spectrum of lung cancer treatments. |
| first_indexed | 2024-03-12T07:30:32Z |
| format | Article |
| id | doaj.art-bb55c13cc617498c875540071aa6275c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:30:32Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-bb55c13cc617498c875540071aa6275c2023-09-02T21:53:13ZengMDPI AGCancers2072-66942019-02-0111226510.3390/cancers11020265cancers11020265MicroRNA in Lung Cancer MetastasisShang-Gin Wu0Tzu-Hua Chang1Yi-Nan Liu2Jin-Yuan Shih3Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 10002, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 10002, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 10002, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei 10002, TaiwanTumor metastasis is a hallmark of cancer, with distant metastasis frequently developing in lung cancer, even at initial diagnosis, resulting in poor prognosis and high mortality. However, available biomarkers cannot reliably predict cancer spreading sites. The metastatic cascade involves highly complicated processes including invasion, migration, angiogenesis, and epithelial-to-mesenchymal transition that are tightly controlled by various genetic expression modalities along with interaction between cancer cells and the extracellular matrix. In particular, microRNAs (miRNAs), a group of small non-coding RNAs, can influence the transcriptional and post-transcriptional processes, with dysregulation of miRNA expression contributing to the regulation of cancer metastasis. Nevertheless, although miRNA-targeted therapy is widely studied in vitro and in vivo, this strategy currently affords limited feasibility and a few miRNA-targeted therapies for lung cancer have entered into clinical trials to date. Advances in understanding the molecular mechanism of metastasis will thus provide additional potential targets for lung cancer treatment. This review discusses the current research related to the role of miRNAs in lung cancer invasion and metastasis, with a particular focus on the different metastatic lesions and potential miRNA-targeted treatments for lung cancer with the expectation that further exploration of miRNA-targeted therapy may establish a new spectrum of lung cancer treatments.https://www.mdpi.com/2072-6694/11/2/265microRNAmetastasislung cancerepithelial-to-mesenchymal transition |
| spellingShingle | Shang-Gin Wu Tzu-Hua Chang Yi-Nan Liu Jin-Yuan Shih MicroRNA in Lung Cancer Metastasis Cancers microRNA metastasis lung cancer epithelial-to-mesenchymal transition |
| title | MicroRNA in Lung Cancer Metastasis |
| title_full | MicroRNA in Lung Cancer Metastasis |
| title_fullStr | MicroRNA in Lung Cancer Metastasis |
| title_full_unstemmed | MicroRNA in Lung Cancer Metastasis |
| title_short | MicroRNA in Lung Cancer Metastasis |
| title_sort | microrna in lung cancer metastasis |
| topic | microRNA metastasis lung cancer epithelial-to-mesenchymal transition |
| url | https://www.mdpi.com/2072-6694/11/2/265 |
| work_keys_str_mv | AT shangginwu micrornainlungcancermetastasis AT tzuhuachang micrornainlungcancermetastasis AT yinanliu micrornainlungcancermetastasis AT jinyuanshih micrornainlungcancermetastasis |