Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

Summary: Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sense cholesterol in the endoplasmic reticulum and nuc...

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Bibliographic Details
Main Authors: George D. Dalton, Seh-Hoon Oh, Linda Tang, Stephanie Zhang, Amanda L. Brown, Venkateshwari Varadharajan, Camelia Baleanu-Gogonea, Valentin Gogonea, Preeti Pathak, J. Mark Brown, Anna Mae Diehl
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:iScience
Subjects:
Lipid
Molecular physiology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221010579

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