Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach

Abstract We investigated gene–environment effects on structural brain endophenotype in bipolar disorder (BD) using a novel method of combining polygenic risk scores with epigenetic signatures since traditional methods of examining the family history and trauma effects have significant limitations. T...

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Bibliographic Details
Main Authors: Bo Hu, Jungwon Cha, Janice M. Fullerton, Sonia Hesam-Shariati, Kunio Nakamura, John I. Nurnberger, Amit Anand
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-01892-3

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