Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice

Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice

Duchenne muscular dystrophy (DMD) is characterized by rapid wasting of skeletal muscle. Mitochondrial dysfunction is a well-known pathological feature of DMD. However, whether mitochondrial dysfunction occurs before muscle fiber damage in DMD pathology is not well known. Furthermore, the impact upon...

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Bibliographic Details
Main Authors: Timothy M. Moore, Amanda J. Lin, Alexander R. Strumwasser, Kevin Cory, Kate Whitney, Theodore Ho, Timothy Ho, Joseph L. Lee, Daniel H. Rucker, Christina Q. Nguyen, Aidan Yackly, Sushil K. Mahata, Jonathan Wanagat, Linsey Stiles, Lorraine P. Turcotte, Rachelle H. Crosbie, Zhenqi Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
muscular dystrophy
Duchenne muscular dystrophy
skeletal muscle
dystrophin
metabolism
mitochondria
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00690/full

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