<i>Cichorium intybus</i> L. Hairy Roots as a Platform for Antimicrobial Activity
Industrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological host...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/2/140 |
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| author | Suvi T. Häkkinen Katarina Cankar Liisa Nohynek Jeroen van Arkel Markus Laurel Kirsi-Marja Oksman-Caldentey Bart Van Droogenbroeck |
| author_facet | Suvi T. Häkkinen Katarina Cankar Liisa Nohynek Jeroen van Arkel Markus Laurel Kirsi-Marja Oksman-Caldentey Bart Van Droogenbroeck |
| author_sort | Suvi T. Häkkinen |
| collection | DOAJ |
| description | Industrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological hosts for the production of several plant-derived molecules. In this study, hairy roots of industrial chicory cultivars were established, and their potential as a source of antimicrobial ingredients was assessed. It was shown that hot water extracts of hairy roots possessed antimicrobial activity against relevant human microbes, whereas corresponding chicory taproots did not show activity. Remarkably, a significant antimicrobial activity of hot water extracts of chicory hairy roots towards methicillin-resistant <i>Staphylococcus aureus</i> was observed, indicating a high potential of hairy roots as a host for production of antimicrobial agents. |
| first_indexed | 2024-03-11T08:18:15Z |
| format | Article |
| id | doaj.art-bb56fc4cc4ca471abb769c581416f2d7 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T08:18:15Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-bb56fc4cc4ca471abb769c581416f2d72023-11-16T22:35:35ZengMDPI AGPharmaceuticals1424-82472023-01-0116214010.3390/ph16020140<i>Cichorium intybus</i> L. Hairy Roots as a Platform for Antimicrobial ActivitySuvi T. Häkkinen0Katarina Cankar1Liisa Nohynek2Jeroen van Arkel3Markus Laurel4Kirsi-Marja Oksman-Caldentey5Bart Van Droogenbroeck6VTT Technical Research Centre of Finland Ltd., Tietotie 2, 02044 Espoo, FinlandWageningen Plant Research, Wageningen University & Research, 6708 PB Wageningen, The NetherlandsVTT Technical Research Centre of Finland Ltd., Tietotie 2, 02044 Espoo, FinlandWageningen Plant Research, Wageningen University & Research, 6708 PB Wageningen, The NetherlandsVTT Technical Research Centre of Finland Ltd., Tietotie 2, 02044 Espoo, FinlandVTT Technical Research Centre of Finland Ltd., Tietotie 2, 02044 Espoo, FinlandILVO Institute for Agriculture, Fisheries and Food Research, 9090 Melle, BelgiumIndustrial chicory is an important crop for its high dietary fibre content. Besides inulin, chicory taproots contain interesting secondary metabolite compounds, which possess bioactive properties. Hairy roots are differentiated plant cell cultures that have shown to be feasible biotechnological hosts for the production of several plant-derived molecules. In this study, hairy roots of industrial chicory cultivars were established, and their potential as a source of antimicrobial ingredients was assessed. It was shown that hot water extracts of hairy roots possessed antimicrobial activity against relevant human microbes, whereas corresponding chicory taproots did not show activity. Remarkably, a significant antimicrobial activity of hot water extracts of chicory hairy roots towards methicillin-resistant <i>Staphylococcus aureus</i> was observed, indicating a high potential of hairy roots as a host for production of antimicrobial agents.https://www.mdpi.com/1424-8247/16/2/140chicoryantimicrobial activityhairy rootssesquiterpenespolyphenolsMRSA |
| spellingShingle | Suvi T. Häkkinen Katarina Cankar Liisa Nohynek Jeroen van Arkel Markus Laurel Kirsi-Marja Oksman-Caldentey Bart Van Droogenbroeck <i>Cichorium intybus</i> L. Hairy Roots as a Platform for Antimicrobial Activity Pharmaceuticals chicory antimicrobial activity hairy roots sesquiterpenes polyphenols MRSA |
| title | <i>Cichorium intybus</i> L. Hairy Roots as a Platform for Antimicrobial Activity |
| title_full | <i>Cichorium intybus</i> L. Hairy Roots as a Platform for Antimicrobial Activity |
| title_fullStr | <i>Cichorium intybus</i> L. Hairy Roots as a Platform for Antimicrobial Activity |
| title_full_unstemmed | <i>Cichorium intybus</i> L. Hairy Roots as a Platform for Antimicrobial Activity |
| title_short | <i>Cichorium intybus</i> L. Hairy Roots as a Platform for Antimicrobial Activity |
| title_sort | i cichorium intybus i l hairy roots as a platform for antimicrobial activity |
| topic | chicory antimicrobial activity hairy roots sesquiterpenes polyphenols MRSA |
| url | https://www.mdpi.com/1424-8247/16/2/140 |
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