Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation
Abstract Background Despite continual progress in the identification and characterization of trait- and disease-associated variants that disrupt transcription factor (TF)-DNA binding, little is known about the distribution of TF binding deactivating mutations (deMs) in enhancer sequences. Here, we f...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-07-01
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Series: | Genome Biology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13059-019-1750-z |