Genetic susceptibility of COVID-19: a systematic review of current evidence
Abstract Introduction While COVID-19 pandemic continues to spread worldwide, researchers have linked patterns of traits to poor disease outcomes. Risk factors for COVID-19 include asthma, elderly age, being pregnant, having any underlying diseases such as cardiovascular disease, diabetes, obesity, a...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-021-00516-8 |
| _version_ | 1818939885633929216 |
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| author | SeyedAhmad SeyedAlinaghi Mohammad Mehrtak Mehrzad MohsseniPour Pegah Mirzapour Alireza Barzegary Pedram Habibi Banafsheh Moradmand-Badie Amir Masoud Afsahi Amirali Karimi Mohammad Heydari Esmaeil Mehraeen Omid Dadras Jean-Marc Sabatier Fabricio Voltarelli |
| author_facet | SeyedAhmad SeyedAlinaghi Mohammad Mehrtak Mehrzad MohsseniPour Pegah Mirzapour Alireza Barzegary Pedram Habibi Banafsheh Moradmand-Badie Amir Masoud Afsahi Amirali Karimi Mohammad Heydari Esmaeil Mehraeen Omid Dadras Jean-Marc Sabatier Fabricio Voltarelli |
| author_sort | SeyedAhmad SeyedAlinaghi |
| collection | DOAJ |
| description | Abstract Introduction While COVID-19 pandemic continues to spread worldwide, researchers have linked patterns of traits to poor disease outcomes. Risk factors for COVID-19 include asthma, elderly age, being pregnant, having any underlying diseases such as cardiovascular disease, diabetes, obesity, and experiencing lifelong systemic racism. Recently, connections to certain genes have also been found, although the susceptibility has not yet been established. We aimed to investigate the available evidence for the genetic susceptibility to COVID-19. Methods This study was a systematic review of current evidence to investigate the genetic susceptibility of COVID-19. By systematic search and utilizing the keywords in the online databases including Scopus, PubMed, Web of Science, and Science Direct, we retrieved all the related papers and reports published in English from December 2019 to September 2020. Results According to the findings, COVID-19 uses the angiotensin-converting enzyme 2 (ACE2) receptor for cell entry. Previous studies have shown that people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) are at high risk of SARS-CoV-2 infection. Also, two studies have shown that males are more likely to become infected with SARS-CoV-2 than females. Besides, research has also shown that patients possessing HLA-B*15:03 genotype may become immune to the infection. Conclusion Combing through the genome, several genes related to immune system’s response were related to the severity and susceptibility to the COVID-19. In conclusion, a correlation was found between the ACE2 levels and the susceptibility to SARS-CoV-2 infection. |
| first_indexed | 2024-12-20T06:30:51Z |
| format | Article |
| id | doaj.art-bb5866d5ed8a437b9dd32b8a061370cf |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-12-20T06:30:51Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-bb5866d5ed8a437b9dd32b8a061370cf2022-12-21T19:50:08ZengBMCEuropean Journal of Medical Research2047-783X2021-05-0126111210.1186/s40001-021-00516-8Genetic susceptibility of COVID-19: a systematic review of current evidenceSeyedAhmad SeyedAlinaghi0Mohammad Mehrtak1Mehrzad MohsseniPour2Pegah Mirzapour3Alireza Barzegary4Pedram Habibi5Banafsheh Moradmand-Badie6Amir Masoud Afsahi7Amirali Karimi8Mohammad Heydari9Esmaeil Mehraeen10Omid Dadras11Jean-Marc Sabatier12Fabricio Voltarelli13Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical SciencesHealthcare Services Management, School of Medicine and Allied Medical Sciences, Ardabil University of Medical SciencesIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical SciencesIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical SciencesSchool of Medicine, Islamic Azad UniversityIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical SciencesBlack Dog Institute, University of New South WalesDepartment of Radiology, School of Medicine, University of California, San Diego (UCSD)School of Medicine, Tehran University of Medical SciencesDepartment of Health Information Technology, Khalkhal University of Medical SciencesDepartment of Health Information Technology, Khalkhal University of Medical SciencesDepartment of Global Health and Socioepidemiology, Graduate School of Medicine, Kyoto UniversityInstitut deNeuro-Physiopathologie (INP), UMR 7051, Faculté de Pharmacie, Université Aix-MarseilleGraduation Program of Health Sciences, Faculty of Medicine, Federal University of Mato GrossoAbstract Introduction While COVID-19 pandemic continues to spread worldwide, researchers have linked patterns of traits to poor disease outcomes. Risk factors for COVID-19 include asthma, elderly age, being pregnant, having any underlying diseases such as cardiovascular disease, diabetes, obesity, and experiencing lifelong systemic racism. Recently, connections to certain genes have also been found, although the susceptibility has not yet been established. We aimed to investigate the available evidence for the genetic susceptibility to COVID-19. Methods This study was a systematic review of current evidence to investigate the genetic susceptibility of COVID-19. By systematic search and utilizing the keywords in the online databases including Scopus, PubMed, Web of Science, and Science Direct, we retrieved all the related papers and reports published in English from December 2019 to September 2020. Results According to the findings, COVID-19 uses the angiotensin-converting enzyme 2 (ACE2) receptor for cell entry. Previous studies have shown that people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) are at high risk of SARS-CoV-2 infection. Also, two studies have shown that males are more likely to become infected with SARS-CoV-2 than females. Besides, research has also shown that patients possessing HLA-B*15:03 genotype may become immune to the infection. Conclusion Combing through the genome, several genes related to immune system’s response were related to the severity and susceptibility to the COVID-19. In conclusion, a correlation was found between the ACE2 levels and the susceptibility to SARS-CoV-2 infection.https://doi.org/10.1186/s40001-021-00516-8Genetic susceptibilityGenetic vulnerabilityGenetic probabilityCOVID-19SARS-CoV-2 |
| spellingShingle | SeyedAhmad SeyedAlinaghi Mohammad Mehrtak Mehrzad MohsseniPour Pegah Mirzapour Alireza Barzegary Pedram Habibi Banafsheh Moradmand-Badie Amir Masoud Afsahi Amirali Karimi Mohammad Heydari Esmaeil Mehraeen Omid Dadras Jean-Marc Sabatier Fabricio Voltarelli Genetic susceptibility of COVID-19: a systematic review of current evidence European Journal of Medical Research Genetic susceptibility Genetic vulnerability Genetic probability COVID-19 SARS-CoV-2 |
| title | Genetic susceptibility of COVID-19: a systematic review of current evidence |
| title_full | Genetic susceptibility of COVID-19: a systematic review of current evidence |
| title_fullStr | Genetic susceptibility of COVID-19: a systematic review of current evidence |
| title_full_unstemmed | Genetic susceptibility of COVID-19: a systematic review of current evidence |
| title_short | Genetic susceptibility of COVID-19: a systematic review of current evidence |
| title_sort | genetic susceptibility of covid 19 a systematic review of current evidence |
| topic | Genetic susceptibility Genetic vulnerability Genetic probability COVID-19 SARS-CoV-2 |
| url | https://doi.org/10.1186/s40001-021-00516-8 |
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